164161-49-3Relevant articles and documents
Novel amide analogues of quinazoline carboxylate display selective antiproliferative activity and potent EGFR inhibition
Malhotra, Anjleena,Bansal, Ranju,Halim, Clarissa Esmeralda,Yap, Celestial T.,Sethi, Gautam,Kumar, Alan Prem,Bishnoi, Mahendra,Yadav, Kamalendra
, p. 2112 - 2122 (2020)
In the present study, a novel series of quinazoline derivatives is developed for cancer therapy. All the synthesised analogues were evaluated against a panel of 60 human cancer cell lines for the antiproliferative activity. Significant and selective growth inhibition of several solid tumour cell lines such as NCI-H322M, NCI-H522 (non-small cell lung cancer), IGROV1, SK-OV-3 (ovarian cancer), TK-10 (renal cancer) and MDA-MB-468 (breast cancer) was observed. Further, all the new amide analogues strongly inhibited EGFR in low nanomolar range with morpholino quinazoline 10 producing activity (IC50 = 6.12 nM) comparable to standard drugs erlotinib and gefitinib. In addition, western blot analysis depicted inhibition of phosphorylation of EGFR by compounds 10 and 11 in MDA-MB-468 cells at 10 μM. Molecular docking studies showed the strong binding interactions with the active site of the EGFR protein. The current investigation could be extremely helpful for the development of newer therapeutically useful quinazoline based molecules for cancer therapy.
QUINAZOLINONE COMPOUNDS
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, (2020/09/12)
New quinazolinone compounds are disclosed, as well as pharmaceutical compositions containing quinazolinones and methods for the treatment of diseases and conditions associated with mitochondrial dysfunction.
HETEROCYCLIC INHIBITORS OF TYROSINE KINASE
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, (2020/11/03)
The present disclosure relates to heterocyclic compounds and methods which may be useful as inhibitors of HER2 or EGFR for the treatment or prevention of disease, including cancer.
