164165-77-9 Usage
Description
1-(2,5-dichloro-3,6-dimethylphenyl)ethanone is an organic compound that serves as an intermediate in the synthesis of various fluorescent dyes and reagents. It is characterized by its unique molecular structure, featuring a dichloro-substituted and dimethyl-substituted phenyl group attached to an ethanone moiety.
Uses
Used in Fluorescent Dye Synthesis:
1-(2,5-dichloro-3,6-dimethylphenyl)ethanone is used as an intermediate in the synthesis of 5(6)-Hexachlorocarboxyfluorescein (C278325), a chlorinated version of 5(6)-Carboxyfluorescein (C178315). 1-(2,5-dichloro-3,6-dimethylphenyl)ethanone is a valuable reagent for the preparation of hydrolytically stable fluorescent conjugates, making it an essential component in the development of new fluorescent probes and dyes.
Used in Research and Diagnostic Applications:
As a starting material for the synthesis of other fluorescein-derived reagents, 1-(2,5-dichloro-3,6-dimethylphenyl)ethanone plays a crucial role in the advancement of research and diagnostic tools. The resulting fluorescent conjugates can be utilized in various fields, including biochemistry, molecular biology, and medical diagnostics, to study molecular interactions, cellular processes, and disease mechanisms.
Check Digit Verification of cas no
The CAS Registry Mumber 164165-77-9 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,6,4,1,6 and 5 respectively; the second part has 2 digits, 7 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 164165-77:
(8*1)+(7*6)+(6*4)+(5*1)+(4*6)+(3*5)+(2*7)+(1*7)=139
139 % 10 = 9
So 164165-77-9 is a valid CAS Registry Number.
InChI:InChI=1S/C10H10Cl2O/c1-5-4-8(11)6(2)9(7(3)13)10(5)12/h4H,1-3H3
164165-77-9Relevant articles and documents
Improved synthetic procedures for 4,7,2′,7′-tetrachloro- and 4′,5′-dichloro-2′,7′-dimethoxy-5(and 6)-carboxyfluoresceins
Lyttle, Matthew H.,Carter, Tim G.,Cook, Ronald M.
, p. 45 - 49 (2001)
Literature syntheses of 4,7,2′,7′-tetrachloro-5(and 6)-carboxyfluorescein ("5 and 6 TET") 1 and 4′,5′-dichloro-2′,7′-dimethoxy-5(and 6)-carboxyfluorescein ("5 and 6 JOE") 2 are reviewed, and new, preparatively useful methods are presented. A three-step synthesis of 1 was developed, which proved to be more efficient than the published seven step synthesis of this compound. The published synthesis of 2 also proved difficult to reproduce, and a better workup of the key intermediate 2-chloro-4-methoxy resorcinol was devised. Isolation of purified single isomers of both dyes is described.
Compositions and methods employing cleavable electrophoretic tag reagents
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, (2008/06/13)
Probe sets for the multiplexed detection of the binding of, or interaction between, one or more ligands and target antiligands are provided. Detection involves the release of identifying tags as a consequence of target recognition. The probe sets include
Trapping the single electron transfer intermediate in an SN2 reaction
Haberfield, Paul
, p. 3314 - 3315 (2007/10/02)
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