1642-54-2 Usage
Description
Diethylcarbamazine Citrate, also known as DEC, is a pharmaceutical compound that serves as an anthelmintic agent. It is a white or almost white crystalline powder with slight hygroscopic properties. Diethylcarbamazine Citrate is formulated into scored white tablets for ease of administration. It is primarily used against filariasis in both humans and animals, making it a valuable tool in combating parasitic infections.
Uses
Used in Pharmaceutical Industry:
Diethylcarbamazine Citrate is used as an anthelmintic agent for the treatment of filariasis, a parasitic infection caused by thread-like worms. It is effective against various species of filarial worms, including Wuchereria bancrofti, Brugia malayi, and Brugia timori, which are responsible for lymphatic filariasis, tropical pulmonary eosinophilia, and elephantiasis.
DIETHYLCARBAMAZINE CITRATE works by inhibiting the metabolism of microfilariae, the larval stage of the filarial worms, leading to their death. This action helps to reduce the worm burden in the host and alleviate the symptoms associated with filariasis.
Additionally, Diethylcarbamazine Citrate is used in veterinary medicine to treat and control filarial infections in animals, contributing to the overall health and well-being of pets and livestock.
Originator
Hetrazan,Lederle,US,1949
Manufacturing Process
To 50 cc of water was added 18 grams of 1-methylpiperazine dihydrochloride
and 8.34 grams of sodium hydroxide. When solution had been effected the
beaker was cooled to 10°C and with stirring, 4.17 grams of sodium hydroxide
dissolved in 15 cc of water and 14 grams of diethyl carbamyl chloride were
added simultaneously. When all had been added, the solution was extracted 3
times with ether which was then dried and filtered. The ether solution was
saturated with dry hydrogen chloride. A yellow gum appeared which on
trituration gave a white, hygroscopic solid which was filtered and dried in a
drying pistol. The N,N-diethyl-4-methyl-1-piperazine-carboxamide
hydrochloride had a melting point of 150°-155°C.If the compound itself is desired, the salt is dissolved in water and the
solution saturated with a mild alkali such as potassium carbonate. The product
is then extracted with chloroform, dried, and after removal of the chloroform,
distilled.
Therapeutic Function
Anthelmintic
Health Hazard
(Non-Specific -- Drugs, n.o.s.) May be fatal if inhaled, swallowed or absorbed through skin. Contact may cause burns to skin and eyes. Fire may produce irritating or poisonous gases. Runoff from fire control or dilution water may cause pollution. The average adult man tolerates a single dose of 1.5 gm without ill effects.
Fire Hazard
When heated to decomposition, DIETHYLCARBAMAZINE CITRATE emits toxic fumes of nitrogen oxides. Avoid decomposing heat.
Safety Profile
Poison by inhalation
and intravenous routes. Moderately toxic by
ingestion, subcutaneous, and intraperitoneal
routes. An experimental teratogen. When
heated to decomposition it emits toxic
fumes of NOx.
Veterinary Drugs and Treatments
Once the hallmark agent for heartworm disease prophylaxis in dogs,
DEC is no longer commercially available in the USA (in oral veterinary
dosage forms). DEC is approved for use for the prophylaxis of
heartworm
disease (D. immitis), and/or the treatment of ascariasis
in dogs. The drug is also used in ferrets and zoo animals susceptible
to heartworm. DEC is used in dogs at higher dosages as alternative
therapy
for several other parasites (see Dosage section below). Some
products were labeled for use in cats to treat ascarid infections.
In cats, DEC may help alleviate the course (preventing lymphoma
development) of FeLV infection.
In the U.K., DEC is used as an injectable product to control parasitic
bronchitis (Dictyocaulus viviparous) in sheep and cattle.
In humans, DEC is indicated as a filaricidal for the treatment
of Wucheria bancrofti, Brugia malayi, Loa loa, and Onchocerca
volvulus.
Check Digit Verification of cas no
The CAS Registry Mumber 1642-54-2 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 1,6,4 and 2 respectively; the second part has 2 digits, 5 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 1642-54:
(6*1)+(5*6)+(4*4)+(3*2)+(2*5)+(1*4)=72
72 % 10 = 2
So 1642-54-2 is a valid CAS Registry Number.
InChI:InChI=1/C10H21N3O.C6H8O7/c1-4-12(5-2)10(14)13-8-6-11(3)7-9-13;7-3(8)1-6(13,5(11)12)2-4(9)10/h4-9H2,1-3H3;13H,1-2H2,(H,7,8)(H,9,10)(H,11,12)/p-3