164267-55-4

Basic information

• Product Name: p-phenylene-3,3'-bis(allyl alcohol)
• Synonyms: p-phenylene-3,3'-bis(allyl alcohol)
• CAS NO: 164267-55-4
• Molecular Weight: 190.242
• Mol File: 164267-55-4.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: p-phenylene-3,3'-bis(allyl alcohol)(CAS DataBase Reference)
• NIST Chemistry Reference: p-phenylene-3,3'-bis(allyl alcohol)(164267-55-4)
• EPA Substance Registry System: p-phenylene-3,3'-bis(allyl alcohol)(164267-55-4)

Safety Data

• Hazardous Substances Data: 164267-55-4(Hazardous Substances Data)

Upstream product

• 7549-44-2 dimethyl-1,4-phenylenediacrylate 

Relevant articles and documents

Synthesis of cell-permeable stapled BH3 peptide-based Mcl-1 inhibitors containing simple aryl and vinylaryl cross-linkers

We report the synthesis of a series of distance-matching aryl and vinylaryl cross-linkers for constructing stapled peptides containing cysteines at i,i+7 positions. Langevin dynamics simulation studies helped to classify these cross-linkers into two categories: the rigid cross-linkers with narrower S-S distance distribution and the flexible cross-linkers with wider S-S distance distribution. The stapled Noxa BH3 peptides with the flexible distance-matching cross-linkers gave the highest degree of helicity as well as the most potent inhibitory activity against Mcl-1. However, the stapled peptides with the highest hydrophobicity showed the most efficient cellular uptake. Together, this work illustrates the divergent nature of binding affinity and cellular uptake, and the vital importance of choosing appropriate cross-linkers in constructing stapled peptides with the drug-like properties.