164290-86-2

Basic information

• Product Name: 3,4-dimethyl-N-phenylbenzamide
• Synonyms: 3,4-dimethyl-N-phenylbenzamide
• CAS NO: 164290-86-2
• Molecular Formula: C₁₅H₁₅NO
• Molecular Weight: 225.2857
• Mol File: 164290-86-2.mol
• Article Data: 6

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 3,4-dimethyl-N-phenylbenzamide(CAS DataBase Reference)
• NIST Chemistry Reference: 3,4-dimethyl-N-phenylbenzamide(164290-86-2)
• EPA Substance Registry System: 3,4-dimethyl-N-phenylbenzamide(164290-86-2)

Safety Data

• Hazardous Substances Data: 164290-86-2(Hazardous Substances Data)

Upstream product

• 723256-69-7 phenyl 3,4-dimethylbenzoate 
• 62-53-3 aniline 
• 21900-23-2 3,4-dimethylbenzoyl chloride 
• 7446-70-0 aluminium trichloride 
• 95-47-6 o-xylene 
• 103-71-9 phenyl isocyanate 
• 619-04-5 3,4-dimethylbenzoic acid 
• 1043925-80-9 N-phenyl-Z-3-chloro-2-(benzylsulfinyl)propenamide 
• 513-81-5 2,3-dimethyl-buta-1,3-diene 
• 201230-82-2 carbon monoxide 
• 31599-61-8 3,4-dimethyliodobenzene 
• 603-79-2 2,3-dimethylbenzoic acid 

Downstream Products

• 16155-55-8 2-(3,4-dimethylphenyl)benzo[d]oxazole 

Relevant articles and documents

Ru(II)-catalyzed ortho-amidation and decarboxylation of aromatic acids: A versatile route to meta-substituted N-aryl benzamides

Carboxylate as a promising and valuable directing group has attracted a great deal of attention. However, employing it as a traceless direction group has rarely been reported. We developed the ruthenium-catalyzed amidation of substituted benzoic acids wit

Interpositus substituted N-aryl benzoyl amines one-step synthesis method of the compound

The invention discloses a one-step synthetic method of meta-substituted N-arylbenzamide compounds. Transition metal ruthenium is used as a catalyst, and the meta-substituted N-arylbenzamide compounds are synthesized in one step through carboxy-based o-C-H functionalization/ decarboxylation coupling reaction of aromatic acid and phenyl isocyanate compounds. The method has the advantages that the raw materials are simple and readily available, the catalyst is cheap, the reaction operation is simple, the utilization rate of atoms is high, the method is environment-friendly and the like.

A convenient synthesis of N-aryl benzamides by rhodium-catalyzed ortho-amidation and decarboxylation of benzoic acids

The rhodium-catalyzed amidation of substituted benzoic acids with isocyanates by directed C-H functionalization followed by decarboxylation to afford the corresponding N-aryl benzamides is demonstrated, in which the carboxylate serves as a unique, removable directing group. Notably, less common meta-substituted N-aryl benzamides are generated readily from more accessible paraor ortho-substituted groups by employing this strategy.