164399-47-7

Basic information

• Product Name: 4-(3-thienyl)benzyl acetate
• Synonyms: 4-(3-thienyl)benzyl acetate
• CAS NO: 164399-47-7
• Molecular Weight: 232.303
• Mol File: 164399-47-7.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 4-(3-thienyl)benzyl acetate(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(3-thienyl)benzyl acetate(164399-47-7)
• EPA Substance Registry System: 4-(3-thienyl)benzyl acetate(164399-47-7)

Safety Data

• Hazardous Substances Data: 164399-47-7(Hazardous Substances Data)

Upstream product

• 127-08-2 potassium acetate 
• 108912-09-0 3-(4-bromomethyl-phenyl)thiophene 
• 16939-05-2 3-(4-tolyl)thiophene 

Downstream Products

• 164399-49-9 2,3-epoxy-4-(3-thienyl)-benzyloxypropane 
• 160278-20-6 3-(4-hydroxymethyl-phenyl)thiophene 

Relevant articles and documents

Synthesis and &β-adrenoceptor blocking activity of some aryloxy- and benzyloxy-propanolamines

4-(3-Thienyl)phenoxypropanolamines 9a-n and 4-(3-thienyl)benzyloxypropanolamines 10a-n have been synthesised starting from 3-(p-tolyl)thiophene (1) and 3-(4-methoxyphenyl)thiophene (2).Compound 1 on treatment with N-bromosuccinimide in refluxing CCl4 using dibenzoylperoxide or 2,2'-azobis(2-methylpropionitrile) as a catalyst gives 4-(3-thienyl)benzyl bromide (4) which on refluxing with AcOK/AcOH yields 4-(3-thienyl)benzyl acetate (5).The acetate 5 on hydrolysis furnishes 4-(3-thienyl)benzyl alcohol (6).Further, 3,4-(methoxyphenyl)thiophene (2) on demethylation yields 4-(3-thienyl)phenol (3).The phenol (3) and alcohol 6 on treatment with epichlorohydrin undergo alkylation to give 2,3-epoxy-4-(3-thienyl)phenoxypropane (7) and 2,3-epoxy-4-(3-thienyl)benzyloxypropane (8) respectively which on condensation with various amines in refluxing ethanol furnish 4-(3-thienyl)phenoxypropanolamines (9) and 4-(3-thienyl)benzyloxypropanolamines (10) respectively.Compounds 9 and 10 have been evaluated for their β-adrenergic blocking activity and a few of them shown moderate β-adrenergic blocking activity.