1644057-79-3Relevant articles and documents
Regioselective addition of Grignard reagents to N-acylpyrazinium salts: Synthesis of substituted 1,2-dihydropyrazines and Δ5-2-oxopiperazines
St Hilaire, Valentine R.,Hopkins, William E.,Miller, Yenteeo S.,Dandepally, Srinivasa R.,Williams, Alfred L.
supporting information, p. 72 - 78 (2019/01/28)
The regioselective addition of Grignard reagents to mono- and disubstituted N-acylpyrazinium salts affording substituted 1,2-dihy-dropyrazines in modest to excellent yields (45–100%) is described. Under acidic conditions, these 1,2-dihydropyrazines can be converted to substituted Δ5-2-oxopiperazines providing a simple and efficient approach towards their preparation.
