16442-79-8

Basic information

• Product Name: 2-amino-1-(2-chlorophenyl)ethan-1-one hydrochloride
• Synonyms: 2-amino-1-(2-chlorophenyl)ethan-1-one hydrochloride;2-AMino-2'-chloroacetophenone HCl
• CAS NO: 16442-79-8
• Molecular Formula: C₈H₈ClNO*ClH
• Molecular Weight: 206.06916
• EINECS: 240-495-2
• Mol File: 16442-79-8.mol
• Article Data: 3

Chemical Properties

• Melting Point: 173-174 °C(Solv: ethanol (64-17-5); hydrochloric acid (7647-01-0))
• Boiling Point: 256.9°Cat760mmHg
• Flash Point: 109.2°C
• Appearance: /
• Density: g/cm³
• Vapor Pressure: 0.015mmHg at 25°C
• CAS DataBase Reference: 2-amino-1-(2-chlorophenyl)ethan-1-one hydrochloride(CAS DataBase Reference)
• NIST Chemistry Reference: 2-amino-1-(2-chlorophenyl)ethan-1-one hydrochloride(16442-79-8)
• EPA Substance Registry System: 2-amino-1-(2-chlorophenyl)ethan-1-one hydrochloride(16442-79-8)

Safety Data

• Hazardous Substances Data: 16442-79-8(Hazardous Substances Data)

Usage

General Description

2-amino-1-(2-chlorophenyl)ethan-1-one hydrochloride is a chemical compound with the molecular formula C8H10ClNO.HCl. It is a hydrochloride salt of 2-amino-1-(2-chlorophenyl)ethan-1-one, which is a substituted phenethylamine derivative. 2-amino-1-(2-chlorophenyl)ethan-1-one hydrochloride is often used as a building block in the synthesis of various pharmaceuticals and organic compounds due to its versatile chemical reactivity and potential pharmacological properties. It is commonly utilized in the pharmaceutical industry as a precursor for the synthesis of other drugs and research compounds. Additionally, it is also used in research settings for its potential biological effects and as a reference compound for analytical purposes.

InChI:InChI=1/C8H8ClNO.ClH/c9-7-4-2-1-3-6(7)8(11)5-10;/h1-4H,5,10H2;1H

Upstream product

• 93102-90-0 2-Amino-3-(2-chloro-phenyl)-3-oxo-propionic acid methyl ester; hydrochloride 
• 89204-91-1 5-(2-Chloro-phenyl)-oxazole-4-carboxylic acid methyl ester 
• 5000-66-8 2-chlorophenacyl bromide 
• 855300-90-2 C₁₀H₈ClNO₃ 

Downstream Products

• 93103-16-3 4-(2-Chloro-phenyl)-1H-imidazole-2-thiol 
• 16442-80-1 2-amino-N-[2-(2-chlorophenyl)-2-oxoethyl]benzamide 
• 23496-56-2 (+/-)-2-amino-1-(2-chlorophenyl)ethanol 

Relevant articles and documents

Preparation method of stable isotope-labeled clorprenaline

The invention relates to a preparation method of stable isotope-labeled clorprenaline. The preparation method comprises the following steps: with 2-bromo-2'-chloroacetophenone as an initial raw material, successively conducting improved Gabriel synthesis (wherein the initial raw material and an amination reagent sodium, namely diformyl amide are subjected to a nucleophilic substitution reaction), hydrolysis, reduction and reductive amination so as to synthesize the isotope-labeled clorprenaline . According to the preparation method disclosed by the invention, through a four-step conventional chemical reaction, process design is reasonable, raw material price is low, an experimental process is controllable, operation is simple and convenient, various required labeled compounds such as D-labeled, 13C-labeled or D/13C double-labeled compounds can be conveniently synthesized, the purity of the prepared target product is high and reaches 98% or above, total yield reaches 66% or above, the isotope abundance of the final product can reach 98% or above, the phenomenon of isotope abundance dilution is avoided, higher reproducibility and stability are achieved, and the obtained target compound can provide a standard reagent for accurately and quantitatively detecting trace residues of clorprenaline.

Syntheses of 2-mercapto-4-substituted imidazole derivatives with antiinflammatory properties

-