164457-19-6Relevant articles and documents
Total synthesis of (±)-8'-trifluoromethyl abscisic acid
Balko, Terry W.,Fields, Stephen C.,Webster, Jeffery D.
, p. 6347 - 6351 (1999)
While 8'-trifluoromethyl ABA (2a) was known to be one of the most active and stable analogs tested in assays for ABA-like activity, a thorough evaluation of its biological properties was limited by compound availability. The current synthesis, which includes the preparation of a previously unknown key intermediate 2-methyl-2-trifluoromethyl-1,4-cyclohexanedione-mono ethylene ketal (18), has been accomplished in 14 steps and 3% yield. The key fluorinated ketal intermediate 18 was prepared in six steps and 20% yield.