1645-58-5

Basic information

• Product Name: 3-BROMO-3,5-DIFLUOROPROPANAL DIETHYL ACETAL
• Synonyms: 3-BROMO-3,5-DIFLUOROPROPANAL DIETHYL ACETAL
• CAS NO: 1645-58-5
• Molecular Formula: C₇H₁₃BrF₂O₂
• Molecular Weight: 247.0777264
• Product Categories: Miscellaneous
• Mol File: 1645-58-5.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 152.4±40.0 °C(Predicted)
• Appearance: /
• Density: 1.362±0.06 g/cm3(Predicted)
• CAS DataBase Reference: 3-BROMO-3,5-DIFLUOROPROPANAL DIETHYL ACETAL(CAS DataBase Reference)
• NIST Chemistry Reference: 3-BROMO-3,5-DIFLUOROPROPANAL DIETHYL ACETAL(1645-58-5)
• EPA Substance Registry System: 3-BROMO-3,5-DIFLUOROPROPANAL DIETHYL ACETAL(1645-58-5)

Safety Data

• Hazardous Substances Data: 1645-58-5(Hazardous Substances Data)

Upstream product

• 64-17-5 ethanol 
• 1993-81-3 ethyl-1,3-dibromo-3,3-difluoropropyl ether 
• 75-61-6 dibromodifluoromethane 
• 109-92-2 ethyl vinyl ether 

Downstream Products

• 70260-27-4 ethyl (E)-3-phenyl-3-fluoro-2-propenoate 
• 105304-62-9 ethyl (2Z)-3-fluoro-3-phenylprop-2-enoate 
• 352-23-8 ethyl 3,3,3-trifluoropropanoate 
• 108221-68-7 ethyl 2-bromo-3,3,3-trifluoropropanoate 
• 407-35-2 ethyl β,β-difluoroacrylate 

Relevant articles and documents

Diethyl 3-bromo-3,3-difluoropropyl acetal: Preparation and SnCl4-promoted cross-coupling reaction with trimethylsilyl enol ethers

The radical addition of dibromodifluoromethane to ethyl vinyl ether in ethanol under Na2S2O4 initiation affords diethyl 3-bromo-3,3-difluoropropyl acetal (1) in high yield. SnCl4-promoted cross-coupling reaction of 1 with trimethylsilyl enol ethers (2) yield γ-bromodifluoromethyl-β-ethoxy ketones (3).

HOT MELT EXTRUDED SOLID DISPERSIONS CONTAINING A BCL2 INHIBITOR

A pro-apoptotic solid dispersion comprises, a Bcl -2 family protein inhibitory compound of Formula A as defined herein, dispersed in a solid matrix that comprises (a) a pharmaceutically acceptable water-soluble polymeric carrier, and (b) a pharmaceutically acceptable surfactant. A process for preparing such a solid dispersion comprises subjecting to elevated temperature the compound of Formula A, the water-soluble polymeric carrier, and the surfactant to provide an extrudable semi-solid mixture; extruding the semi-solid mixture; and cooling the resulting extrudate to provide a solid matrix comprising the polymeric carrier, and the surfactant and having the compound dispersed in essentially non-crystalline form therein. The solid dispersion is suitable for oral administration to a subject in need thereof for treatment of a disease characterized by overexpression of one or more anti-apoptotic Bcl -2 family proteins, for example cancer or an immune or autoimmune disease.

A convenient synthesis of ethyl 3,3,3,-trifluoropropanoate and its 2-bromo derivative

Ethyl 3,3,3-trifluoropropanoate and ethyl 2-bromo-3,3,3-trifluoropropanoate have been synthesized. A common intermediate ethyl 3-chloro (or 3-bromo)-3,3-difluoropropanoate is involved in the two syntheses. These esters are obtained by oxidation of the corresponding acetals resulting from the radical addition of CF2BrCl or CF2Br2 to ethyl vinyl ether.