16458-77-8

Basic information

• Product Name: 3-phenylthiazolo<3,2-a>benzimidazole
• Synonyms: 3-phenylthiazolo<3,2-a>benzimidazole
• CAS NO: 16458-77-8
• Molecular Weight: 250.324
• Mol File: 16458-77-8.mol
• Article Data: 11

Chemical Properties

• CAS DataBase Reference: 3-phenylthiazolo<3,2-a>benzimidazole(CAS DataBase Reference)
• NIST Chemistry Reference: 3-phenylthiazolo<3,2-a>benzimidazole(16458-77-8)
• EPA Substance Registry System: 3-phenylthiazolo<3,2-a>benzimidazole(16458-77-8)

Safety Data

• Hazardous Substances Data: 16458-77-8(Hazardous Substances Data)

Upstream product

• 103-72-0 phenyl isothiocyanate 
• 6077-10-7 bis(phenylethynyl)mercury 
• 28100-28-9 1,3-dihydro-benzoimidazole-2-thione; mercury(II) salt (2:1) 
• 51-17-2 benzoimidazole 
• 5153-67-3 nitrostyrene 
• 98-86-2 acetophenone 
• 134469-07-1 Benzimidazol-2-thiol 
• 102-96-5 (2-nitroethenyl)benzene 
• 536-74-3 phenylacetylene 
• 100-52-7 benzaldehyde 
• 71022-74-7 (E)-1,2-diiodostyrene 
• 95-54-5 1,2-diamino-benzene 
• 932-87-6 1-Bromo-2-phenylacetylene 
• 7436-90-0 2,2-dibromostyrene 

Downstream Products

• 22902-36-9 2,3-diphenylbenzo[4,5]imidazo[2,1-b]thiazole 
• 37654-65-2 2-bromo-3-phenylbenzo[4,5]imidazo[2,1-b]thiazole 
• 62459-43-2 9-methyl-3-phenyl[1,3]thiazolo[3,2-a]benzimidazol-9-ium iodide 

Relevant articles and documents

Metal-Free Synthesis of Imidazo[2,1-b]thiazoles from Thioimidazoles and Ketones Mediated by Selectfluor

This paper presents a practical and efficient strategy for the preparation of imidazol[2,1-b]-thiazoles from thioimidazoles and ketones mediated by Selectfluor. The proposed mechanism suggests that this transformation took place through electrophilic thiolation at an α-carbon of ketones by sulfur cation, which is produced by the oxidation of thioimidazole by Selectfluor. This metal-free protocol tolerated various ketones, including methyl ketones or non-methyl ketones, aryl ketones or aliphatic ketones. The experimental results indicated that steric hindrance of the substituents at the α-position of ketones or on the aromatic ring of aryl ketones had significant influence on the yields of imidazol[2,1-b]-thiazoles. Thioimidazole and benzothioimidazoles were well tolerated while 5-substituted benzothioimidazoles provided the mixture of the corresponding 6-substituted and 7-substituted benzoimidazo[2,1-b]thiazole products.

Polysubstituted benzimidazothiazole, derivative and synthesis method of polysubstituted benzimidazothiazole

The invention relates to polysubstituted benzimidazothiazole, a derivative and a synthesis method of the polysubstituted benzimidazothiazole. According to the method, in the air atmosphere for the first time, a benzimidazole compound, a beta-nitrostyrolene compound and sulfur powder are promoted to be converted into benzo [4, 5] imidazo [2, 1-b] thiazole and a derivative by an acid, and the prepared benzo [4, 5] imidazo [2, 1-b] thiazole is stable in molecular structure and excellent in chemical property. Reaction raw materials of the synthesis method are cheap and easy to obtain, pretreatmentis not needed, and the atom economy of the reaction is high; only cheap aromatic acid needs to be used in the reaction, environmental pollution is reduced, raw materials are saved, and reaction costis reduced; the whole reaction system is simple, reaction conditions are mild, reaction equipment is less, experimental operation is simple and convenient, and material sources are wide.

A benzo imidazo [2, 1 - b] thiazole derivatives

The invention discloses a preparation method of a benzimidazo[2,1-b]thiazole derivative. According to the method, the benzimidazo[2,1-b]thiazole derivative is synthesized by one step of performing reaction on a 2-thioimidazole compound serving as a raw ma