16460-75-6

Basic information

• Product Name: (2R)-2-Phenyl-1-butanol
• Synonyms: (2R)-2-Phenyl-1-butanol;[R,(-)]-2-Phenyl-1-butanol;[R,(-)]-β-Ethylphenethyl alcohol;(2R)-1-Phenyl-2-butanol;(R)-1-Phenyl-2-butanol;[(R)-2-Hydroxybutyl]benzene;(R)-2-PHENYLBUTAN-1-OL
• CAS NO: 16460-75-6
• Molecular Formula: C₁₀H₁₄O
• Molecular Weight: 150.22
• Mol File: 16460-75-6.mol
• Article Data: 35

Chemical Properties

• Appearance: /
• CAS DataBase Reference: (2R)-2-Phenyl-1-butanol(CAS DataBase Reference)
• NIST Chemistry Reference: (2R)-2-Phenyl-1-butanol(16460-75-6)
• EPA Substance Registry System: (2R)-2-Phenyl-1-butanol(16460-75-6)

Safety Data

• Hazardous Substances Data: 16460-75-6(Hazardous Substances Data)

Upstream product

• 4286-15-1 (S)-2-phenylbutyric acid 
• 938-79-4 (2R)-2-phenylbutanoic acid 
• 106-88-7 (R)-(+)-1,2-epoxybutane 
• 71-43-2 benzene 
• 108-22-5 Isopropenyl acetate 
• 2035-94-1 2-phenylbutan-1-ol 
• 109686-82-0 RS-2-phenylbutyrate 
• 104499-21-0 (4R,5S)-3-<(2R)-phenylbutanoyl>-4-methyl-5-phenyl-1,3-oxazolidine-2-thione 
• 159345-11-6 (S)-N-((1S,2S)-2-Hydroxy-1-methyl-2-phenyl-ethyl)-N-methyl-2-phenyl-butyramide 
• 158779-92-1 (-)-8-Phenylmenthyl (R)-2-phenylbutyrate 
• 108-05-4 vinyl acetate 
• 104196-23-8 (2S,3S)-2,3-epoxy-3-phenyl-1-propanol 
• 31729-70-1 bis(iodozinc)methane 
• 42307-60-8 (S)-2-methylbutanal 

Downstream Products

• 33204-52-3 (2R)-cyclohexyl-1-butanol 
• 20068-14-8 (+)-(S)-1-Chlor-2-phenyl-butan 
• 26798-31-2 (-)-2-Phenyl-1-butyl-α-naphthylcarbamat 
• 1195590-62-5 (S)-heptan-3-ylbenzene 
• 1043500-12-4 ((R)-1-iodomethyl-propyl)benzene 
• 1043495-96-0 (4S)-4-((2S)-2-phenylbutyl)-4,5-dihydro-1,3-oxazol-2-ylamine 
• 1043500-14-6 (2R,5S)-2-isopropyl-3,6-dimethoxy-5-((S)-2-phenylbutyl)-2,5-dihydropyrazine 
• 1043500-17-9 (2S,4S)-2-amino-4-phenylhexanoic acid methyl ester 
• 1043500-22-6 (2S,4S)-2-amino-4-phenylhexan-1-ol 

Relevant articles and documents

DIFFERENCES IN REACTIVITY AND ENANTIOSELECTIVITY IN LIPASE REACTIONS WITH CARBOXYLIC ESTERS AND ALCOHOLS BEARING THE SAME STEREOGENIC CENTER

The reaction rate and stereochemical outcome of lipase reactions obtained with carboxylic esters and alcohols, which contain the same stereogenic center, can be modulated by changing the mode of the lipase reaction, i.e. ester hydrolysis versus alcohol acetylation.

Identification of an Esterase Isolated Using Metagenomic Technology which Displays an Unusual Substrate Scope and its Characterisation as an Enantioselective Biocatalyst

Evaluation of an esterase annotated as 26D isolated from a marine metagenomic library is described. Esterase 26D was found to have a unique substrate scope, including synthetic transformations which could not be readily effected in a synthetically useful manner using commercially available enzymes. Esterase 26D was more selective towards substrates which had larger, more sterically demanding substituents (i. e. iso-propyl or tert-butyl groups) on the β-carbon, which is in contrast to previously tested commercially available enzymes which displayed a preference for substrates with sterically less demanding substituents (e.g. methyl group) at the β-carbon. (Figure presented.).

Generation and Application of (Diborylmethyl)zinc(II) Species: Access to Enantioenriched gem-Diborylalkanes by an Asymmetric Allylic Substitution

We report the successful generation of (diborylmethyl)zinc(II) species by transmetallation beteween isolable (diborylmethyl)lithium and zinc(II) halide (X=Br, Cl) and their application in the synthesis of enantioenriched gem-diborylalkanes bearing a stereogenic center at the β-position of the diboryl groups by an asymmetric allylic substitution reaction. The reaction has a broad substrate scope, and various enantioenriched gem-diborylalkanes can be obtained in good yields with excellent enantioselectivity. Further elaboration of the enantioenriched gem-diborylalkanes provides access to a diverse set of valuable chiral building blocks.