164662-42-4 Usage
Description
1-(2,4-dichlorophenyl)-6-fluoro-4-oxo-7-(piperazin-1-yl)-1,4-dihydroquinoline-3-carboxylic acid is a synthetic chemical compound that belongs to the quinolone class of antibiotics. It is structurally related to the fluoroquinolone family and contains a fluorine atom, a piperazin-1-yl group, and a carboxylic acid functional group, which contribute to its biological activity. 1-(2,4-dichlorophenyl)-6-fluoro-4-oxo-7-(piperazin-1-yl)-1,4-dihydroquinoline-3-carboxylic acid has been studied for its potential pharmaceutical applications, particularly in the areas of antibacterial and antifungal properties.
Uses
Used in Pharmaceutical Industry:
1-(2,4-dichlorophenyl)-6-fluoro-4-oxo-7-(piperazin-1-yl)-1,4-dihydroquinoline-3-carboxylic acid is used as an antimicrobial agent for its potential to inhibit the growth of various pathogenic microorganisms. Its unique structure and promising antimicrobial activity make it a subject of interest for further research and development in the field of medicinal chemistry.
Used in Antibacterial Applications:
1-(2,4-dichlorophenyl)-6-fluoro-4-oxo-7-(piperazin-1-yl)-1,4-dihydroquinoline-3-carboxylic acid is used as an antibacterial agent to combat bacterial infections. Its ability to inhibit the growth of various pathogenic bacteria makes it a valuable compound for the development of new antibiotics.
Used in Antifungal Applications:
1-(2,4-dichlorophenyl)-6-fluoro-4-oxo-7-(piperazin-1-yl)-1,4-dihydroquinoline-3-carboxylic acid is used as an antifungal agent to treat fungal infections. Its potential to inhibit the growth of various pathogenic fungi highlights its usefulness in the development of new antifungal medications.
Check Digit Verification of cas no
The CAS Registry Mumber 164662-42-4 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,6,4,6,6 and 2 respectively; the second part has 2 digits, 4 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 164662-42:
(8*1)+(7*6)+(6*4)+(5*6)+(4*6)+(3*2)+(2*4)+(1*2)=144
144 % 10 = 4
So 164662-42-4 is a valid CAS Registry Number.
164662-42-4Relevant articles and documents
Effect of Lipophilicity at N-1 on Activity of Fluoroquinolones against Mycobacteria
Renau, Thomas E.,Sanchez, Joseph P.,Shapiro, Martin A.,Dever, Julie A.,Gracheck, Stephen J.,Domagala, John M.
, p. 2974 - 2977 (2007/10/02)
The dramatic increase in drug resistant Mycobacterium tuberculosis has caused a resurgence in research targeted toward these organisms.As part of a systematic study to optimize the quinolone antibacterials against mycobacteria, we have prepared a series of N-1-phenyl-substituted derivatives to explore the effect of increasing lipophilicity on potency at this position.The compounds, synthesized by the modification of a literature procedure, were evaluated for activity against Gram-negative and Gram-positive bacteria, Mycobacterium fortuitum and Mycobacterium smegmatis, and the results correlated with log P, pKa, and other attributes.The activity of the compounds against the rapidly growing, less hazardous organism M. fortuitum was used as a measure of M. tuberculosis activity.The results demonstrate that increasing lipophilic character by itself does not correlate with increased potency against mycobacteria.Rather, intrinsic activity against Gram-negative and/or Gram-positive bacteria is the governing factor for corresponding activity against mycobacteria.
