164713-03-5Relevant articles and documents
Application of asymmetric ylide cyclopropanation in the total synthesis of halicholactone
Zhu, Chun-Yin,Cao, Xiao-Yu,Zhu, Ben-Hu,Deng, Chao,Sun, Xiu-Li,Wang, Bi-Qin,Shen, Qi,Tang, Yong
, p. 11465 - 11468 (2009)
A study was conducted to demonstrate the application of asymmetric ylide cyclopropanation in the total synthesis of halicholactone. The synthesis of the intermediate started with the enantioselective cyclopropanation of acrylate with the ylide derived fro
The total asymmetric synthesis of halicholactone and neohalicholactone
Critcher, Douglas J.,Connolly, Stephen,Wills, Martin
, p. 3763 - 3766 (2007/10/02)
Completion of the first total synthesis of the marine natural products Halicholactone and Neohalicholactone is reported. The key step is a moderately stereoselective coupling between a vinylic anion and an aldehyde. An unexpectedly slow desilylation due t