164917-35-5

Basic information

• Product Name: 4-(3'-pyrrolidin-1''-ylpropoxy)benzaldehyde
• Synonyms: 4-(3'-pyrrolidin-1''-ylpropoxy)benzaldehyde
• CAS NO: 164917-35-5
• Molecular Weight: 233.31
• Mol File: 164917-35-5.mol
• Article Data: 11

Chemical Properties

• CAS DataBase Reference: 4-(3'-pyrrolidin-1''-ylpropoxy)benzaldehyde(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(3'-pyrrolidin-1''-ylpropoxy)benzaldehyde(164917-35-5)
• EPA Substance Registry System: 4-(3'-pyrrolidin-1''-ylpropoxy)benzaldehyde(164917-35-5)

Safety Data

• Hazardous Substances Data: 164917-35-5(Hazardous Substances Data)

Upstream product

• 22041-21-0 methyl 3-(pyrrolidin-1-yl)propanoate 
• 39743-20-9 1-(3-chloropropyl)pyrrolidine 
• 123-08-0 4-hydroxy-benzaldehyde 
• 123-75-1 pyrrolidine 
• 17954-81-3 4-(3-bromopropoxy)benzaldehyde 
• 109-70-6 1.3-chlorobromopropane 
• 19748-66-4 3-pyrrolidin-1-yl-propan-1-ol 
• 57616-69-0 1-(3-chloropropyl)pyrrolidine hydrochloride 
• 82625-25-0 4-(3-chloropropoxy)benzaldehyde 

Downstream Products

• 1158961-36-4 C₁₉H₂₉FN₂O 
• 1158961-38-6 C₁₈H₂₇FN₂O 
• 1186403-39-3 C₂₁H₂₃N₃O₂ 

Relevant articles and documents

Design, synthesis and anticholinesterase activity of novel benzylidenechroman-4-ones bearing cyclic amine side chain

A series of 3-(4-(aminoalkoxy)benzylidene)-chroman-4-ones 7a-r were designed and synthesized as analogs of homoisoflavonoids which are well known natural products with diverse pharmacological properties related to Alzheimer's disease. The in vitro anti-cholinesterase activity of designed compounds 7a-r against AChE and BuChE, revealed that compounds bearing piperidinylethoxy residue showed potent activity against AChE at sub-micromolar level (IC50 values = 0.122-0.207 μM), more potent than reference drug tacrine. The structure-activity relationships study of piperidinylethoxy series demonstrated that the selectivity and physicochemical properties of compounds could be optimized by selection of a proper substituent on the C-7 position of chroman ring, while the high potency of the molecule against AChE was reserved.

IMIDAZO [2, 1-F] [1, 2, 4] TRIAZIN-4-AMINE DERIVATIVES AS TLR7 AGONIST

Disclosed herein is an imidazo [2, 1-f] [1, 2, 4] triazin-4-amine derivative or a stereoisomer thereof, or a pharmaceutically acceptable salt thereof useful as a TLR7 agonist, and a pharmaceutical composition comprising the same. Also disclosed herein is a method of treating cancer using the imidazo [2, 1-f] [1, 2, 4] triazin-4-amine derivative or a stereoisomer thereof, or a pharmaceutically acceptable salt thereof as TLR7 agonist.

Development of chalcone-O-alkylamine derivatives as multifunctional agents against Alzheimer's disease

A series of novel chalcone-O-alkylamine derivatives were designed, synthesized and evaluated as multifunctional anti-Alzheimer's disease agents. Based on the experimental results, compound 23c exhibited good inhibitory potency on both acetylcholinesterase