16493-63-3 Usage
Description
(S)-(+)-3-hydroxy-4,4,4-trichlorobutyric beta-lac, also known as (S)-tetrachlorolactone, is a chiral cyclic ester with the molecular formula C4H3Cl3O2. It features a single chiral center and is one of two enantiomers, the other being its mirror image, (R)-(-)-3-hydroxy-4,4,4-trichlorobutyric beta-lactone. (S)-(+)-3-hydroxy-4,4,4-trichlorobutyric beta-lac is characterized by its potential to form stable lactone ring structures and is utilized as a crucial precursor in the synthesis of various pharmaceuticals and agrochemicals.
Uses
Used in Pharmaceutical Synthesis:
(S)-(+)-3-hydroxy-4,4,4-trichlorobutyric beta-lac is used as a key precursor in the pharmaceutical industry for the synthesis of various drugs. Its unique chemical structure allows for the creation of complex molecules with potential therapeutic applications.
Used in Agrochemical Production:
In the agrochemical industry, (S)-(+)-3-hydroxy-4,4,4-trichlorobutyric beta-lac serves as an essential starting material for the development of new pesticides and other agricultural chemicals. Its incorporation into these products can lead to enhanced efficacy and selectivity in controlling pests and diseases.
Used in Chiral Chemistry Research:
Due to its chiral nature, (S)-(+)-3-hydroxy-4,4,4-trichlorobutyric beta-lac is also utilized in the field of chiral chemistry research. It can be employed as a building block or a reference compound for studying the effects of stereochemistry on the properties and reactivity of molecules, which is crucial for understanding biological activity and developing enantiomerically pure drugs.
Check Digit Verification of cas no
The CAS Registry Mumber 16493-63-3 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 1,6,4,9 and 3 respectively; the second part has 2 digits, 6 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 16493-63:
(7*1)+(6*6)+(5*4)+(4*9)+(3*3)+(2*6)+(1*3)=123
123 % 10 = 3
So 16493-63-3 is a valid CAS Registry Number.
16493-63-3Relevant articles and documents
Stereoselective synthesis of cis- or trans-2,4-disubstituted butyrolactones from Wynberg lactone
Ganta, Ashok,Shamshina, Julia L.,Cafiero, Lauren R.,Snowden, Timothy S.
experimental part, p. 5396 - 5405 (2012/09/08)
(R)-Wynberg lactone was used to prepare various asymmetric 2,4-disubstituted butyrolactones in three to four steps. Attainment of any possible stereoisomer, based upon commencement from (R)- or (S)-4- trichloromethyl-2-oxetanone, and the capacity to insta
Polymeric Cinchona Alkaloids as Catalysts in the Enantioselective 2,2-Cycloaddition Reaction of Ketene and Chloral
Song, Choong Eui,Ryu, Tae Hee,Roh, Eun Joo,Kim, In O,Ha, Hyun-Joon
, p. 1215 - 1218 (2007/10/02)
Poly(cinchona alkaloid-co-acrylonitrile) 1a-d and poly(cinchona alkaloid acrylate) 2a-b catalyze the enantioselective cycloaddition of ketene to chloral for the preparation of (R)- and (S)-β-(trichloromethyl)-β-propiolactone.Copolymers 1a-d showed relatively lower catalytic activity with moderate enantioselectivity (22-59percent e.e.), while homopolymers 2a-b gave similar catalytic activity and enantioselectivity (60-94percent e.e.) compared to those of their monomeric alkaloids as catalysts.The polymeric effect was observed with poly(acryloyl quinidine) 2a as catalyst to get the best enantioselectivity of 94percent e.e. at the temperature -30 deg C.
