16499-54-0

Basic information

• Product Name: 2-AMino-5-trifluoroMethylbenzaMide
• Synonyms: 2-AMino-5-trifluoroMethylbenzaMide
• CAS NO: 16499-54-0
• Molecular Formula: C₈H₇F₃N₂O
• Molecular Weight: 204.1491896
• Mol File: 16499-54-0.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 258.3±40.0 oC (760 Torr), Calc.*
• Flash Point: 110.0±27.3 oC, Calc.*
• Appearance: /
• Density: 1.418±0.06 g/cm3 (20 oC 760 Torr), Calc.*
• PKA: 15.08±0.50(Predicted)
• CAS DataBase Reference: 2-AMino-5-trifluoroMethylbenzaMide(CAS DataBase Reference)
• NIST Chemistry Reference: 2-AMino-5-trifluoroMethylbenzaMide(16499-54-0)
• EPA Substance Registry System: 2-AMino-5-trifluoroMethylbenzaMide(16499-54-0)

Safety Data

• Hazardous Substances Data: 16499-54-0(Hazardous Substances Data)

Usage

General Description

2-Amino-5-trifluoromethylbenzamide is an organic compound that contains an amino group and a trifluoromethyl group attached to a benzene ring. It is commonly used as a building block in the synthesis of pharmaceuticals and agrochemicals. 2-AMino-5-trifluoroMethylbenzaMide has been found to exhibit anti-inflammatory and analgesic properties, and it has been studied for its potential use in treating various diseases and conditions. Its unique chemical structure and properties make it a valuable tool for researchers and chemists in the development of new medicinal compounds.

Upstream product

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Relevant articles and documents

Copper-Catalyzed One-Pot Synthesis of Quinazolinones from 2-Nitrobenzaldehydes with Aldehydes: Application toward the Synthesis of Natural Products

A novel, efficient, and atom-economical approach for the construction of quinazolinones from 2-nitrobenzaldehydes has been unveiled via copper-catalyzed nitrile formation, hydrolysis, and reduction in one pot for the first time. In this reaction, urea is used as a source of nitrogen for nitrile formation, hydrazine hydrate is used for both the reduction of the nitro group and the hydrolysis of nitrile, and atmospheric oxygen is used as the sole oxidant. The method portrays a wide substrate scope with good functional group tolerances. Moreover, this method was applied for the synthesis of schizocommunin, tryptanthrin, phaitanthrin-A, phaitanthrin-B, and 8H-quinazolino[4,3-b]quinazolin-8-one.

Synthesis and Nematicidal Activities of 1,2,3-Benzotriazin-4-one Derivatives against Meloidogyne incognita

A series of novel 1,2,3-benzotriazin-4-one derivatives were synthesized by the reaction of 3-bromoalkyl-1,2,3-benzotriazin-4-ones with potassium salt of 2-cyanoimino-4-oxothiazolidine in the presence of potassium iodide. Nematicidal assays in vivo showed that some of them exhibited good control efficacy against the cucumber root-knot nematode disease caused by Meloidogyne incognita, up to 100% at the concentration of 10.0 mg L-1, which indicated that 1,2,3-benzotriazin-4-one derivatives might be potential for novel promising nematicides. The nematicidal activity was influenced by the combination of substituent type, substituted position, and linker length in the molecule. The inhibition rate data at the concentrations of 5.0 and 1.0 mg L-1 for the compounds with high inhibitory activities were also provided. When tested in vitro, none of them showed direct inhibition against M. incognita. The investigation of a significant difference between in vivo and in vitro data is in progress.