16503-81-4

Basic information

• Product Name: 2-((4-chlorophenyl)thio)-2,2-difluoroacetic acid
• Synonyms: 2-((4-chlorophenyl)thio)-2,2-difluoroacetic acid
• CAS NO: 16503-81-4
• Molecular Weight: 238.642
• Mol File: 16503-81-4.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: 2-((4-chlorophenyl)thio)-2,2-difluoroacetic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 2-((4-chlorophenyl)thio)-2,2-difluoroacetic acid(16503-81-4)
• EPA Substance Registry System: 2-((4-chlorophenyl)thio)-2,2-difluoroacetic acid(16503-81-4)

Safety Data

• Hazardous Substances Data: 16503-81-4(Hazardous Substances Data)

Upstream product

• 106-54-7 p-Chlorothiophenol 
• 76-04-0 2-chloro-2,2-difluoroacetic acid 
• 1895-39-2 sodium chlorodifluoroacetate 
• 18803-44-6 sodium p-chlorothiophenolate 
• 676316-30-6 4-chlorophenylthiodifluoroacetic acid chloride 

Downstream Products

• 1563062-31-6 ethyl ({[(4-chlorophenyl)sulfanyl]difluoromethyl}sulfanyl)methanethioate 
• 1563062-69-0 4-[(4-chlorophenyl)sulfanyl]-2-[(ethoxymethanethioyl)sulfanyl]-4,4-difluorobutyl acetate 
• 1563062-70-3 ethyl ({4-[(4-chlorophenyl)sulfanyl]-1-cyano-4,4-difluorobutan-2-yl}sulfanyl)methanethioate 
• 1563062-79-2 (4-chlorophenyl)(1,1-difluoro-2-(4-isopropylcyclohex-1-enyl)ethyl)sulfane 
• 1563062-82-7 2-(4-(4-chlorophenylthio)-4,4-difluorobutyl)phthalimide 
• 1563062-84-9 2-[(6-chloro-2,2-difluoro-3,4-dihydro-2H-1-benzothiopyran-4-yl)methyl]-2,3-dihydro-1H-phthalimide 
• 1563062-49-6 ethyl ({4-[(4-chlorophenyl)sulfanyl]-1-(1,3-dioxo-2,3-dihydro-1H-isoindol-2-yl)-4,4-difluorobutan-2-yl}sulfanyl)methanethioate 
• 1563062-96-3 6-chloro-2,2-difluoro-4-[(pentafluorophenyl)methyl]-3,4-dihydro-2H-1-benzothiopyran 
• 1563063-04-6 ethyl ({4-[(4-chlorophenyl)sulfanyl]-4,4-difluoro-1-[N-(4-methoxyphenyl)methanesulfonamido]butan-2-yl}sulfanyl)methanethioate 
• 1563063-05-7 N-[(6-chloro-2,2-difluoro-3,4-dihydro-2H-1-benzothiopyran-4-yl)methyl]-N-(4-methoxyphenyl)methanesulfonamide 
• 1563063-08-0 C₁₈H₁₈ClF₂NO₃S₂ 
• 1563062-54-3 ethyl ({4-[(4-chlorophenyl)sulfanyl]-1-(2,6-dioxopiperidin-1-yl)-4,4-difluorobutan-2-yl}sulfanyl)methanethioate 
• 1563062-56-5 methyl 12-[(4-chlorophenyl)sulfanyl]-10-[(ethoxymethanethioyl)sulfanyl]-12,12-difluorododecanoate 
• 1563063-02-4 3-(6-chloro-2,2-difluorothiochroman-4-yl)-1-(4-methoxyphenyl)propan-1-one 

Relevant articles and documents

Silver-Catalyzed C-H Aryloxydifluoromethylation and Arylthiodifluoromethylation of Heteroarenes

The oxidative C-H aryloxydifluoromethylation and arylthiodifluoromethylation of heteroaromatic compounds through the decarboxylation of easily accessible aryloxydifluoroacetic acids and arylthiodifluoroacetic acids, respectively, are disclosed. These reac

Fluorodecarboxylation: Synthesis of aryl trifluoromethyl ethers (ArOCF3) and thioethers (ArSCF3)

Fluorodecarboxylation of aryloxydifluoroacetic acid (ArOCF2CO2H) and arylmercaptodifluoroacetic acid (ArSCF2CO2H) towards ArXCF3 (X = O, S) using silver (I) salts in the presence of Selectfluor in a biphasic system with trifluoroacetic acid additive is discussed.