165460-96-8

Basic information

• Product Name: (-)-α,α-dideutero-m-octopamine
• CAS NO: 165460-96-8
• Molecular Weight: 155.165
• Mol File: 165460-96-8.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (-)-α,α-dideutero-m-octopamine(CAS DataBase Reference)
• NIST Chemistry Reference: (-)-α,α-dideutero-m-octopamine(165460-96-8)
• EPA Substance Registry System: (-)-α,α-dideutero-m-octopamine(165460-96-8)

Safety Data

• Hazardous Substances Data: 165460-96-8(Hazardous Substances Data)

Upstream product

• 100-83-4 meta-hydroxybenzaldehyde 
• 53313-95-4 α,3-dihydroxybenzeneacetonitrile 

Relevant articles and documents

Synthesis of [11C](-)-α,α-dideutero-phenylephrine for in vivo kinetic isotope studies

(-)-[11C]Phenylephrine and positron emission tomography could potentially be used to assess neuronal monoamine oxidase activity in the heart. Previous data for (-)-[11C]phenylephrine indicated that, although its retention and neuronal selectivity parallel that of the neuronal mapping agent (-)-[11C]hydroxyephedrine, its neuronal storage and clearance properties are quite different. In order to study the in vivo kinetics of (-)-[11C]phenylephrine in greater detail, the dideutero analog [11C]-(-)-α,α-dideutero-phenylephrine, was synthesized by [11C]methylation of the precursor (-)-α,α-dideutero-m-octopamine. The key step in the procedure was BD3 reduction of the cyanohydrin derived from 3-hydroxybenzaldehyde. Deuterium incorporation at the alpha positions of m-octopamine was confirmed by NMR and mass spectroscopy of the deuterated product and by comparison of spectral data with undeuterated m-octopamin, (-)-α,α-Dideutero-m-octopamine was methylated with CF3SO311CH3 to give suitable for animal and clinical studies.