165589-89-9

Basic information

• Product Name: 5',3'-O-(tetraisopropyldisiloxane-1,3-diyl)-2'-O-(phenylaminecarbothioate)uridine
• Synonyms: 5',3'-O-(tetraisopropyldisiloxane-1,3-diyl)-2'-O-(phenylaminecarbothioate)uridine
• CAS NO: 165589-89-9
• Molecular Weight: 621.902
• Mol File: 165589-89-9.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: 5',3'-O-(tetraisopropyldisiloxane-1,3-diyl)-2'-O-(phenylaminecarbothioate)uridine(CAS DataBase Reference)
• NIST Chemistry Reference: 5',3'-O-(tetraisopropyldisiloxane-1,3-diyl)-2'-O-(phenylaminecarbothioate)uridine(165589-89-9)
• EPA Substance Registry System: 5',3'-O-(tetraisopropyldisiloxane-1,3-diyl)-2'-O-(phenylaminecarbothioate)uridine(165589-89-9)

Safety Data

• Hazardous Substances Data: 165589-89-9(Hazardous Substances Data)

Upstream product

• 69304-38-7 3',5'-(1,1,3,3-tetraisopropyldisiloxane-1,3-diyl)uridine 
• 1082068-88-9 5',3'-O-(tetraisopropyldisiloxane-1,3-diyl)-2'-1-imidazole thionocarbamate 
• 62-53-3 aniline 
• 103-72-0 phenyl isothiocyanate 

Downstream Products

• 98495-56-8 3',5'-O-(tetraisopropyldisiloxane-1,3-diyl)-2'-deoxyuridine 
• 1082068-98-1 2'-O-phenylamine-carbothioate uridine 
• 1219089-76-5 2'-O-(phenylaminecarbothioate)-5'-O-(4,4'-dimethoxytrityl)-uridine-3'-O-(β-cyanoethyl)-N,N-diisopropyl-phosphoramidite 

Relevant articles and documents

Thiocarbon-protecting groups for RNA synthesis

Aspects of the invention include 2'-protected nucleoside monomers that are protected at the 2'-site with thiocarbon protecting groups. Thiocarbon protecting groups of interest include thiocarbonate, thionocarbonate, dithiocarbonate groups, as well as thionocarbamate protecting groups. Aspects of the invention further include nucleic acids that include the protecting groups of the invention, as well as methods of synthesizing nucleic acids using the protecting groups of the invention.

PROTECTED MONOMER AND METHOD OF FINAL DEPROTECTION FOR RNA SYNTHESIS

A nucleoside monomer that is protected by a thionocarbamate protecting group is provided, as well as a method for making a polynucleotide that uses the same. Also provided is a polynucleotide synthesis method that employs a diamine to deprotect a protected polynucleotide.