16563-48-7Relevant articles and documents
Potential hypotensive agents: Synthesis and hypotensive activity of oxime ethers derived from 1-naphthoxepines and related compounds
Tandon, Vishnu K.,Kumar, Manoj,Awasthi, Anoop K.,Saxena, Hari O.,Goswamy, Gajendra K.
, p. 3177 - 3180 (2007/10/03)
The synthesis and pharmacological evaluation of substituted oximino-ethers 1 and 2 of naphth[1,2-b]- and naphth[2,1-b]-oxepin-5-ones (4 and 8) were carried out. The hypotensive activity of oximino-ethers 1 and 2 was evaluated on anaesthetized cats. The results indicated that 1c caused a fall of 80mm/Hg for >100′ at a dose of 5mg/kg iv in anaesthetized cats.
An improved two-step regioselective synthesis of naphth- and naphthoxepin-5-ones
Tandon, V. K.,Chhor, R. B.,Goswamy, G. K.
, p. 1027 - 1029 (2007/10/03)
An improved regioselective synthesis of naphthoxepin-5-one 1 and naphthoxepin-5-one 2 has been described. The key step is one-step regioselective synthesis of 4-naphthoxybutanoic acids 3 and 4, formed from the corresponding naphthols, and their cyclisation to naphthoxepinones 1 and 2.
