165740-03-4 Usage
Description
Desloratadine N-Carboxylic Acid Methyl Ester is an impurity of Desloratadine (D290250), a nonsedating-type histamine H1-receptor antagonist. It is a chemical compound that is formed during the synthesis process of Desloratadine and is considered an unwanted byproduct.
Uses
Used in Pharmaceutical Industry:
Desloratadine N-Carboxylic Acid Methyl Ester is used as an impurity in the production of Desloratadine, a nonsedating antihistamine drug. It is important to monitor and control the levels of this impurity to ensure the safety and efficacy of the final drug product.
Desloratadine N-Carboxylic Acid Methyl Ester is used as a research compound for studying the synthesis process and impurity profile of Desloratadine. This helps in optimizing the manufacturing process and improving the quality of the final drug product.
Check Digit Verification of cas no
The CAS Registry Mumber 165740-03-4 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,6,5,7,4 and 0 respectively; the second part has 2 digits, 0 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 165740-03:
(8*1)+(7*6)+(6*5)+(5*7)+(4*4)+(3*0)+(2*0)+(1*3)=134
134 % 10 = 4
So 165740-03-4 is a valid CAS Registry Number.
165740-03-4Relevant articles and documents
Loratadine and analogues: Discovery and preliminary structure-activity relationship of inhibitors of the amino acid transporter B0AT2
Cuboni, Serena,Devigny, Christian,Hoogeland, Bastiaan,Strasser, Andrea,Pomplun, Sebastian,Hauger, Barbara,H?fner, Georg,Wanner, Klaus T.,Eder, Matthias,Buschauer, Armin,Holsboer, Florian,Hausch, Felix
, p. 9473 - 9479 (2014)
B0AT2, encoded by the SLC6A15 gene, is a transporter for neutral amino acids that has recently been implicated in mood and metabolic disorders. It is predominantly expressed in the brain, but little is otherwise known about its function. To identify inhibitors for this transporter, we screened a library of 3133 different bioactive compounds. Loratadine, a clinically used histamine H1 receptor antagonist, was identified as a selective inhibitor of B0AT2 with an IC50 of 4 μM while being less active or inactive against several other members of the SLC6 family. Reversible inhibition of B0AT2 was confirmed by electrophysiology. A series of loratadine analogues were synthesized to gain insight into the structure-activity relationships. Our studies provide the first chemical tool for B0AT2.
