165800-07-7 Usage
Description
Zoledronate disodium tetrahydrate, also known as Zometa, is a third-generation bisphosphonate that was developed as part of a medicinal chemistry program at Novartis, Switzerland, in 1986. It is a white crystalline powder that is introduced in Canada as a lyophilized powder in vials for infusion as a solution. Zoledronate disodium tetrahydrate is a potent inhibitor of hypercalcemia induced by vitamin D, showing significantly higher potency than its predecessor, pamidronate.
Uses
Used in Oncology:
Zoledronate disodium tetrahydrate is used as an anti-hypercalcemic agent for the treatment of tumor-induced hypercalcemia. It is highly effective in normalizing serum calcium concentrations in cancer patients, with a 5-minute infusion being more convenient than the 2-hour infusion required for pamidronate.
Used in Osteoporosis Treatment:
Zoledronate disodium tetrahydrate is used as an osteoporosis treatment agent, as it was initially developed to discover a follow-up to pamidronate for the treatment of osteoporosis and metastatic bone disease. Its potent inhibitory effect on bone resorption makes it a valuable option for managing osteoporosis.
Used in Metastatic Bone Disease:
Zoledronate disodium tetrahydrate is also used in the treatment of metastatic bone disease, where it helps to reduce the risk of skeletal-related events such as bone fractures and the need for radiation or surgery to manage bone complications.
Originator
Novartis (Switzerland)
Check Digit Verification of cas no
The CAS Registry Mumber 165800-07-7 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,6,5,8,0 and 0 respectively; the second part has 2 digits, 0 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 165800-07:
(8*1)+(7*6)+(6*5)+(5*8)+(4*0)+(3*0)+(2*0)+(1*7)=127
127 % 10 = 7
So 165800-07-7 is a valid CAS Registry Number.
InChI:InChI=1/C5H10N2O7P2.2Na/c8-5(15(9,10)11,16(12,13)14)3-7-2-1-6-4-7;;/h1-2,4,8H,3H2,(H2,9,10,11)(H2,12,13,14);;/q;2*+1/p-2
