16588-25-3Relevant articles and documents
Compound Shape Effects in Minor Groove Binding Affinity and Specificity for Mixed Sequence DNA
Guo, Pu,Farahat, Abdelbasset A.,Paul, Ananya,Harika, Narinder K.,Boykin, David W.,Wilson, W. David
, p. 14761 - 14769 (2018)
AT specific heterocyclic cations that bind in the DNA duplex minor groove have had major successes as cell and nuclear stains and as therapeutic agents which can effectively enter human cells. Expanding the DNA sequence recognition capability of the minor
Ureido-containing benzimidazole derivative as well as preparation method and application thereof
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Paragraph 0082-0085; 0098; 0100-0102, (2021/05/26)
The invention discloses a ureido-containing benzimidazole derivative, whose structural general formula is shown as a formula (I). The invention also discloses a preparation method of the compound and application of the compound in the preparation of medicines for resisting chronic kidney diseases. The derivative is an inhibitor of selective homologous domain interacting protein kinase-2 (HIPK2), can lower the protein level of the HIPK2 at the same time to play a dual role, has an inhibition effect on the HIPK2 kinase and protein level, a fibrosis signal molecule smad3 and an inflammation signal molecule I[kappa]B-alpha phosphorylation level, can adjust the fibrosis and inflammation processes at the same time, and has a good market application prospect as chronic kidney disease treatment medicines.
Bipolar material and organic light emitting diode element
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Paragraph 0033, (2019/04/14)
The invention provides a bipolar material in which carbazole is linked with benzimidazole carbon nitrogen and an organic light emitting diode element utilizing the bipolar material. The organic lightemitting diode element comprises a substrate, a first conducting layer, an electric hole transfer layer, a light emitting layer, an electronic transfer layer and a second conducting layer, wherein thefirst conducting layer is arranged on the substrate; the electric hole transfer layer is arranged on the first conducting layer; the light emitting layer is arranged on the electric hole transfer layer and comprises the bipolar material in which carbazole is linked with benzimidazole carbon nitrogen; and the electronic transfer layer is arranged on the electronic transfer layer.