165898-25-9

Basic information

• Product Name: 1-(N-(N^α-(4-benzoylbenzoyl)-L-biocytinoyl)amino)-6-(N'-boc-amino)hexane
• Synonyms: 1-(N-(N^α-(4-benzoylbenzoyl)-L-biocytinoyl)amino)-6-(N'-boc-amino)hexane
• CAS NO: 165898-25-9
• Molecular Weight: 779.014
• Mol File: 165898-25-9.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 1-(N-(N^α-(4-benzoylbenzoyl)-L-biocytinoyl)amino)-6-(N'-boc-amino)hexane(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(N-(N^α-(4-benzoylbenzoyl)-L-biocytinoyl)amino)-6-(N'-boc-amino)hexane(165898-25-9)
• EPA Substance Registry System: 1-(N-(N^α-(4-benzoylbenzoyl)-L-biocytinoyl)amino)-6-(N'-boc-amino)hexane(165898-25-9)

Safety Data

• Hazardous Substances Data: 165898-25-9(Hazardous Substances Data)

Upstream product

• 1351229-72-5 C₂₁H₂₄N₂O₄ 
• 1188371-91-6 (S)-6-tert-butoxycarbonyl-2-(4-benzoylbenzoylamino)hexanoic acid methyl ester 
• 2389-48-2 N-ε-tert-butoxycarbonyl-L-lysine methyl ester hydrochloride 
• 611-95-0 4-carboxybenzophenone 
• 576-19-2 biocytin 
• 91990-88-4 p-benzoylbenzoic acid N-hydroxysuccinimide ester 
• 65915-94-8 N-(tert-butoxycarbonyl)-1,6-diaminohexane hydrochloride 
• 165898-24-8 N^α-(4-benzoylbenzoyl)-L-biocytin 

Relevant articles and documents

Target identification of anti-diabetic and anti-obesity flavonoid derivative (Fla-CN)

Fla-CN is a flavonoid derivative with anti-diabetic and anti-obesity effects; however, its biological targets are still unknown. In this study, we developed bifunctional affinity-based probes to identify the direct targets of Fla-CN. When using probe 3, we observed the co-location of probe 3 and mitochondria in both HepG2 and 3T3-L1 cells. The putative target proteomes were obtained using activity-based protein profiling (ABPP) and photo-affinity labelling. Pyruvate carboxylase, mitochondrial malate dehydrogenase, mitochondrial complex I, and F1FO-ATPase were validated as the direct targets of Fla-CN by surface plasmon resonance (SPR) and biochemical assays. It was elucidated that the Tyr651, Gln870 and Lys912 were the key amino acid residues near the binding site of pyruvate carboxylase with Fla-CN. The direct interaction of Fla-CN and the above four targets allowed elucidation of its complicated molecular mechanism, including the activation of adenosine 5-monophosphate (AMP)-activated protein kinase (AMPK), and the inhibition of gluconeogenesis. Further investigation for activation of AMPK in normal and insulin resistance (IR) HepG2 cells, indicated that Fla-CN could target insulin resistance tissues.