16597-31-2Relevant articles and documents
Preparation of (R)-3-hydroxy-n-methylpiperidine, a synthetic key intermediate of (R)-mepenzolate, based on the lipase-catalyzed resolution of the racemic form
Yamashita, Yasunobu,Hanaya, Kengo,Shoji, Mitsuru,Sugai, Takeshi
, p. 370 - 379 (2019/05/21)
In this study, a two-step method for the gram-scale synthesis of (R)-3-hydroxy-N-methylpiperidine in 97.8% enantiomeric excess (ee) is reported. The key chiral synthetic intermediate of (R)-mepenzolate was formed in 22% yield over two steps using a commer