16597-36-7Relevant articles and documents
MACROHETEROCYCLES. XXII. N,N'-DIALKYLDIAZA(OXA)CYCLOALKANETHIONES, SYNTHESIS AND PROPERTIES
Bogat-skii, A. V.,Luk'yanenko, N. G.,Kirichenko, T. I.,Limich, V. V.,Nazarova, N. Yu.,Karpenko, L. P.
, p. 1379 - 1385 (2007/10/02)
During the alkylation of diaza(oxa)cycloalkanethiones with halogenoalkanes in a two-phase system in the presence of potassium carbonate the corresponding N,N'-dialkylthiuronium salts are formed.Heating of the latter under vacuum leads to the elimination of the halogenoalkanes and the formation of N,N'-dialkyldiaza(oxa)cycloalkanethiones, including new crown compounds.The cationic selectivity of the latter with respect to the ions of alkali and alkaline-earth metals was determined.
Cyclic Urea and Thiourea Derivatives as Inducers of Murine Erythroleukemia Differentiation
Li, Chau-der,Mella, Sharon L.,Sartorelli, Alan C.
, p. 1089 - 1092 (2007/10/02)
A series of derivatives of tetramethylurea, a known inducer of the differentiation of Friend erythroleukemia cells, has been synthesized and tested for its capacity to induce erythroid maturation, as measured by the synthesis of hemoglobin.Cyclic urea and thiourea derivatives consisting of five-, six-, and seven-membered ring systems containing N-alkyl substituents were prepared.Most of these agents were relatively effective inducers of differentiation, with N-alkyl substitution appearing to be essential for maximum response.The most potent agents developed wereN,N'-dimethyl cyclic ureas.Exposure to concentrations of 2 to 4 mM of these derivatives resulted in more than 90percent of the cell population achieving a differentiated state.Under these conditions, the parent compound, tetramethylurea, was slightly less efficacious, causing differentiation of only 68percent of the population at its maximum effective level of 4 mM.
