16601-02-8Relevant articles and documents
Design and synthesis of garlic-related unsymmetrical thiosulfonates as potential Alzheimer's disease therapeutics: In vitro and in silico study
Zilbeyaz, Kani,Oztekin, Aykut,Kutluana, Emine Gunbatar
, (2021/05/13)
Garlic contains a wide range of organosulfur compounds, which exhibit a broad spectrum of biological activities. Amongst the sulfur-containing compounds in garlic, the thiosulfonates are considerably popular in various fields. In light of this, we decided
Synthesis of Ajoene Analogues by Novel Synthetic Strategies
Yamamoto Raynbird, Marina,Khokhar, Shaista S.,Neef, Daniel,Evans, Gareth J. S.,Wirth, Thomas
supporting information, p. 3008 - 3012 (2021/02/03)
Ajoene is a compound found in garlic extracts exhibiting a large range of biological activity. Novel ajoene analogues have been prepared in the search of compounds with superior bioactivity. Modifications include the alteration of the sulfoxide, the centr
Phenylboronic acid-catalyzed tandem construction of S-S and C-S bonds: a new method for the synthesis of benzyl disulfanylsulfone derivatives fromS-benzyl thiosulfonates
Jannapu Reddy, Raju,Rama Krishna, Gamidi,Waheed, Md.
supporting information, p. 3243 - 3248 (2020/05/14)
A unique phenylboronic acid-catalyzed dimerization-sulfonylation ofS-benzyl thiosulfonates has been disclosed. A metal-free tandem construction of S-S and C-S bonds is an operationally simple method to access a wide range of benzyl disulfanylsulfone derivatives in high to excellent yields. Moreover, the robustness of this tandem transformation has been demonstrated by gram-scale reactions, and a plausible mechanism is also proposed.
