16601-23-3

Basic information

• Product Name: 1,2-Cyclopropanedicarboxylic acid, 3,3-dimethyl-, dimethyl ester, trans-
• CAS NO: 16601-23-3
• Molecular Formula: C9H14O4
• Molecular Weight: 186.208
• Mol File: 16601-23-3.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 1,2-Cyclopropanedicarboxylic acid, 3,3-dimethyl-, dimethyl ester, trans-(CAS DataBase Reference)
• NIST Chemistry Reference: 1,2-Cyclopropanedicarboxylic acid, 3,3-dimethyl-, dimethyl ester, trans-(16601-23-3)
• EPA Substance Registry System: 1,2-Cyclopropanedicarboxylic acid, 3,3-dimethyl-, dimethyl ester, trans-(16601-23-3)

Safety Data

• Hazardous Substances Data: 16601-23-3(Hazardous Substances Data)

Upstream product

• 594-16-1 2,2-dibromopropane 
• 624-49-7 dimethylfumarate 
• 594-20-7 2,2-dichloropropane 
• 624-48-6 dimethyl cis-but-2-ene-1,4-dioate 

Relevant articles and documents

CYCLOPROPANATION OF DIMETHYL FUMARATE AND MALEATE WITH GEM-DIHALIDES CATALYZED BY Co(0)- OR Ni(0)-COMPLEX AND ZINC.

The reaction of bis(acetonitrile)bis(diethyl fumarate)cobalt(0) with dibromomethane gave diethyl trans-1,2-cyclopropanedicarboxylate in a 67% yield based on the cobalt complex. Dimethyl cis-1,2-cyclopropanedicarboxylate was obtained in a 52% yield from the reaction of dimethyl maleate with dibromomethane in the presence of acetonitrilebis(dimethyl maleate)nickel(0) accompanied by the formation of the trans-isomer in a 14% yield. The addition of zinc gave cyclopropanes in over 100% yields based on cobalt or nickel. 3-Methyl- and 3,3-dimethyl-1,2-cyclopropanedicarboxylic acid esters were produced by the reaction of dimethyl fumarate or maleate with 1,1-dibromoethane and 2,2-dibromopropane. The yield in the cobalt catalyst system decreases with an increase of substituents of gem-dibromides, while that in the nickel catalyst system does not vary appreciably.