16618-52-3

Basic information

• Product Name: N-(3,5-dimethylphenyl)formamide
• Synonyms: N-(3,5-dimethylphenyl)formamide
• CAS NO: 16618-52-3
• Molecular Weight: 149.192
• Mol File: 16618-52-3.mol
• Article Data: 23

Chemical Properties

• CAS DataBase Reference: N-(3,5-dimethylphenyl)formamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-(3,5-dimethylphenyl)formamide(16618-52-3)
• EPA Substance Registry System: N-(3,5-dimethylphenyl)formamide(16618-52-3)

Safety Data

• Hazardous Substances Data: 16618-52-3(Hazardous Substances Data)

Upstream product

• 124-38-9 carbon dioxide 
• 108-69-0 3,5-dimethylaminoaniline 
• 2043-61-0 cyclohexanecarbaldehyde 
• 4913-13-7 3,5,N,N-tetramethylaniline 
• 54132-75-1 3,5-dimethylphenyl isocyanate 
• 96-26-4 dihydroxyacetone 
• 62034-72-4 N-hydroxy-3,5-dimethylbenzamide 
• 77287-34-4 formamide 
• 6613-44-1 3,5-dimethylbenzoyl chloride 
• 522629-38-5 N-(3,5-dimethyl-phenyl)-2-iodo-acetamide 
• 68-12-2 N,N-dimethyl-formamide 
• 2258-42-6 formyl acetic anhydride 
• 64-18-6 formic acid 
• 667-27-6 Ethyl bromodifluoroacetate 

Downstream Products

• 20600-56-0 1-isocyano-3,5-dimethylbenzene 
• 65772-54-5 N-(3,5-dimethylphenyl)-N-methylformamide 
• 1097629-29-2 N-(2,6-dichloro-5-ethyl-pyrimidin-4-yl)-N-(3,5-dimethyl-phenyl)-formamide 
• 291275-22-4 2,4-dichloro-5-isopropyl-6-[N-(3',5'-dimethylphenyl)formylamido]pyrimidine 
• 13342-20-6 N-methyl-3,5-dimethylaniline 

Relevant articles and documents

Diverse catalytic reactivity of a dearomatized PN3P?-nickel hydride pincer complex towards CO2 reduction

A dearomatized PN3P?-nickel hydride complex has been prepared using an oxidative addition process. The first nickel-catalyzed hydrosilylation of CO2 to methanol has been achieved, with unprecedented turnover numbers. Selective methylation and formylation of amines with CO2 were demonstrated by such a PN3P?-nickel hydride complex, highlighting its versatile functions in CO2 reduction.

A Catalyst-Free Process for the Direct Oxidative Synthesis of Form-anilides from Arylamines and Aldehydes under Air Atmosphere

An efficient and catalyst-free process for the direct oxidative synthesis of formanilides from primary aromatic amines and aliphatic aldehydes has been developed under mild aerobic oxidation conditions. The isotope-labeling experiments indicated that the oxygen atom of the formanilide originated from dioxygen.

A NHC-silyliumylidene cation for catalytic N?formylation of amines using carbon dioxide

This study describes the use of a silicon(II) complex, namely, the NHC-silyliumylidene cation complex [(IMe)2SiH]I (1, IMe =:C{N(Me)C(Me)}2), to catalyze the chemoselective N-formylation of primary and secondary amines using CO2 and PhSiH3 under mild conditions to afford the corresponding formamides as a sole product (average reaction time: 4.5 h; primary amines, average yield: 95%, average TOF: 8 h?1; secondary amines, average yield: 98%, average TOF: 17 h?1). The activity of 1 and product yields outperform the currently available non-transition-metal catalysts used for this catalysis. Mechanistic studies show that the silicon(II) center in complex 1 catalyzes the C?N bond formation via a different pathway in comparison with non-transition-metal catalysts. It sequentially activates CO2, PhSiH3, and amines, which proceeds via a dihydrogen elimination mechanism, to form formamides, siloxanes, and dihydrogen gas.

An efficient method for the N-formylation of amines under catalyst- and additive-free conditions

A simple catalyst- and additive-free method for the N-formylation of amines has been developed. The advantages of this protocol include a wide range of functional group tolerance, high efficiency and a lack of required extra promoters under mild conditions. This convenient strategy will provide a facile synthesis towards N-formamide natural products and pharmaceutical derivatives. A mechanism that involves difluorocarbene is proposed for this reaction.