166180-94-5 Usage
Description
[1,4'-Bipiperidine]-1',4'-dicarboxylic acid, 2-oxo-, 1'-(phenylmethyl) ester is a chemical compound characterized by the molecular formula C23H24N2O5. It is an ester derived from 1,4'-bipiperidine-1',4'-dicarboxylic acid, which features two piperidine rings. [1,4'-Bipiperidine]-1',4'-dicarboxylic acid, 2-oxo-, 1'-(phenylmethyl)
ester is recognized for its potential utility as a building block in the synthesis of various organic compounds and pharmaceuticals. Its unique structure and properties also suggest possible applications in medicinal chemistry and drug discovery, although further research is necessary to explore its full potential.
Uses
Used in Pharmaceutical Synthesis:
[1,4'-Bipiperidine]-1',4'-dicarboxylic acid, 2-oxo-, 1'-(phenylmethyl) ester is used as a key building block in the pharmaceutical industry for the synthesis of organic compounds and pharmaceuticals. Its unique structure allows for the creation of a wide range of molecules with potential therapeutic applications.
Used in Medicinal Chemistry:
In the field of medicinal chemistry, [1,4'-Bipiperidine]-1',4'-dicarboxylic acid, 2-oxo-, 1'-(phenylmethyl) ester is utilized as a structural component in the development of new drugs. Its properties may contribute to the discovery of novel therapeutic agents with improved efficacy and selectivity.
Used in Drug Discovery:
[1,4'-Bipiperidine]-1',4'-dicarboxylic acid, 2-oxo-, 1'-(phenylmethyl)
ester is also used in drug discovery processes to identify new molecular entities with potential biological activities. Its incorporation into various chemical libraries can facilitate the screening and optimization of lead compounds for specific therapeutic targets.
Check Digit Verification of cas no
The CAS Registry Mumber 166180-94-5 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,6,6,1,8 and 0 respectively; the second part has 2 digits, 9 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 166180-94:
(8*1)+(7*6)+(6*6)+(5*1)+(4*8)+(3*0)+(2*9)+(1*4)=145
145 % 10 = 5
So 166180-94-5 is a valid CAS Registry Number.
166180-94-5Relevant articles and documents
Design, synthesis, and SAR of tachykinin antagonists: Modulation of balance in NK1/NK2 receptor antagonist activity
Albert, Jeffrey S.,Andisik, Donald,Barthlow, Herbert,Bernstein, Peter R.,Bialecki, Russell A.,Dedinas, Robert,Dembofsky, Bruce T.,Hill, Daniel,Kirkland, Karin,Koether, Gerard M.,Kosmider, Benedict J.,Ohnmacht, Cyrus,Palmer, William,Potts, William,Rumsey, William,Shen, Lihong,Shenvi, Ashok,Sherwood, Scott,Aharony, David,Warwick, Paul J.,Russell, Keith
, p. 3972 - 3983 (2007/10/03)
Through optimization of compounds based on the dual NK1/NK2 antagonist ZD6021, it was found that alteration of two key regions could modulate the balance of NK1 and NK2 potency. Substitution of the 2-naphthalene position in analogues of ZD6021 resulted in increased NK1 potency and thus afforded NK1 preferential antagonists. Alterations of the piperidine region could then increase NK2 potency to restore dual NK1/NK2 selectivity. Through these efforts, three novel receptor antagonists from a single chemically related series were identified; two are dual NK1/NK2 antagonists, and the third is an NK1 preferential antagonist. In this paper, the factors affecting the balance of NK1 and NK2 selectivity in this series are discussed and the in vitro and in vivo properties of the novel antagonists are described.
Cyclic amide derivatives for treating asthma
-
, (2008/06/13)
Compounds of formula I STR1 wherein Q1, Q2, Q3, and Q4 have any of the meanings given in the specification, their N-oxides, and their pharmaceutically acceptable salts are nonpeptide antagonists of neurokinin A and useful for the treatment of asthma, etc. Also disclosed are pharmaceutical compositions, processes for preparing the compounds of formula I and intermediates.
