166196-11-8 Usage
Description
1-[(2,6-Difluorophenyl)methyl]-1H-1,2,3-triazole-4-carboxylic acid is a chemical compound characterized by its unique molecular structure, which features a triazole ring fused with a phenyl group substituted with two fluorine atoms. 1-[(2,6-Difluorophenyl)methyl]-1H-1,2,3-triazole-4-carboxylic acid has potential applications in various industries due to its distinct chemical properties.
Uses
Used in Pharmaceutical Industry:
1-[(2,6-Difluorophenyl)methyl]-1H-1,2,3-triazole-4-carboxylic acid is used as a key intermediate in the synthesis of various pharmaceutical compounds. Its unique structure allows for the development of new drugs with improved efficacy and selectivity, making it a valuable asset in drug discovery and design.
Used in Chemical Synthesis:
In the field of chemical synthesis, 1-[(2,6-Difluorophenyl)methyl]-1H-1,2,3-triazole-4-carboxylic acid serves as a versatile building block for the creation of a wide range of chemical products. Its reactivity and structural diversity enable the synthesis of complex molecules with specific properties, such as novel materials, agrochemicals, and specialty chemicals.
Used in Material Science:
1-[(2,6-Difluorophenyl)methyl]-1H-1,2,3-triazole-4-carboxylic acid can be utilized in the development of advanced materials with unique properties. Its incorporation into polymers, for example, can lead to materials with enhanced thermal stability, mechanical strength, and chemical resistance, making them suitable for various applications in the automotive, aerospace, and electronics industries.
Used in Research and Development:
As a novel chemical entity, 1-[(2,6-Difluorophenyl)methyl]-1H-1,2,3-triazole-4-carboxylic acid holds significant potential for research and development purposes. It can be employed as a model compound to study various chemical reactions and mechanisms, as well as to explore new synthetic routes and methodologies in organic chemistry.
Check Digit Verification of cas no
The CAS Registry Mumber 166196-11-8 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,6,6,1,9 and 6 respectively; the second part has 2 digits, 1 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 166196-11:
(8*1)+(7*6)+(6*6)+(5*1)+(4*9)+(3*6)+(2*1)+(1*1)=148
148 % 10 = 8
So 166196-11-8 is a valid CAS Registry Number.
166196-11-8Relevant articles and documents
Highly regioselective and sustainable solar click reaction: A new post-synthetic modified triazole organic polymer as a recyclable photocatalyst for regioselective azide-alkyne cycloaddition reaction
Yadav, Dolly,Singh, Nem,Kim, Tae Wu,Kim, Jae Young,Park, No-Joong,Baeg, Jin-Ook
supporting information, p. 2677 - 2685 (2019/06/13)
The synthesis of pharmaceutically active 1,2,3-triazoles has been continuously scrutinized in the search for unique and effective catalysts to make the process efficient, green, and sustainable. Here, we are presenting a new visible light active Ni(ii) cyclam-integrated triazole-linked organic polymer (Ni-TLOP) photocatalyst for the synthesis of 1,2,3-triazole compounds with excellent efficiency and regioselectivity. The reaction was studied for a series of substrates and the absolute regioselectivity of a representative triazole product has also been confirmed by X-ray crystallography. The proficiency and chemical orthogonality of the Ni-TLOP are remarkable and it shows enhanced efficiency and regioselectivity. The use of a recyclable photocatalyst and non-hazardous reagents makes the catalytic system sustainable and environmentally friendly. This photocatalyzed click reaction technique has been successfully applied to the expedient synthesis of one of the most sold anti-epileptic drugs rufinamide.
SUBSTITUTED TRIAZOLES AND METHODS RELATING THERETO
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Page/Page column 34, (2016/08/23)
Substituted 1,2,3-triazole compounds are disclosed which have utility in the treatment of a variety of neurological disorders. The compounds provided herein have the general structure wherein R1, R2, R3 and n are as defined herein, including stereoisomers, esters, solvates and pharmaceutically acceptable salts thereof. Also disclosed are compositions containing a compound provided herein in combination with a pharmaceutically acceptable carrier, as well as methods relating to the use thereof for treating neurological disorders in a subject in need thereof.
PROCESS FOR PREPARATION OF RUFINAMIDE
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Page/Page column 7, (2013/07/25)
The present invention relates to a novel process for preparation of rufinamide (I) comprising: reacting 2,6-difluorobenzyl azide (II) and propiolic acid (III) in a mixture of alcohol and water to produce 1-(2,6-difluorobenzyl)-1H-1,2,3-triazole-4-carboxyl