166282-28-6

Basic information

• Product Name: Carbamic acid, [3-[cyclopropyl(5,6,7,8,9,10-hexahydro-4-hydroxy-2-oxo-2H-cycloocta[b ]pyran-3-yl)methyl]phenyl]-, phenylmethyl ester
• CAS NO: 166282-28-6
• Molecular Formula: C29H31NO5
• Molecular Weight: 473.569
• Mol File: 166282-28-6.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: Carbamic acid, [3-[cyclopropyl(5,6,7,8,9,10-hexahydro-4-hydroxy-2-oxo-2H-cycloocta[b ]pyran-3-yl)methyl]phenyl]-, phenylmethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: Carbamic acid, [3-[cyclopropyl(5,6,7,8,9,10-hexahydro-4-hydroxy-2-oxo-2H-cycloocta[b ]pyran-3-yl)methyl]phenyl]-, phenylmethyl ester(166282-28-6)
• EPA Substance Registry System: Carbamic acid, [3-[cyclopropyl(5,6,7,8,9,10-hexahydro-4-hydroxy-2-oxo-2H-cycloocta[b ]pyran-3-yl)methyl]phenyl]-, phenylmethyl ester(166282-28-6)

Safety Data

• Hazardous Substances Data: 166282-28-6(Hazardous Substances Data)

Upstream product

• 100058-82-0 5,6,7,8,9,10-Hexahydro-4-hydroxy-2H-cyclooctapyran-2-on 
• 162174-77-8 m-<(benzyloxycarbonyl)amino>phenyl cyclopropyl carbinol 

Downstream Products

• 166282-70-8 3-<(3-aminophenyl)cyclopropylmethyl>-5,6,7,8,9,10-hexahydro-4-hydroxy-2H-cyclooctapyran-2-one 
• 166334-72-1 N-{3-[Cyclopropyl-(4-hydroxy-2-oxo-5,6,7,8,9,10-hexahydro-2H-cycloocta[b]pyran-3-yl)-methyl]-phenyl}-2-phenyl-acetamide 
• 166335-16-6 4-Cyano-N-{3-[(R)-cyclopropyl-(4-hydroxy-2-oxo-5,6,7,8,9,10-hexahydro-2H-cycloocta[b]pyran-3-yl)-methyl]-phenyl}-benzenesulfonamide 
• 166335-16-6 4-Cyano-N-{3-[(S)-cyclopropyl-(4-hydroxy-2-oxo-5,6,7,8,9,10-hexahydro-2H-cycloocta[b]pyran-3-yl)-methyl]-phenyl}-benzenesulfonamide 

Relevant articles and documents

Structure-based design of nonpeptidic HIV protease inhibitors from a cyclooctylpyranone lead structure

Recently, the novel cyclooctylpyranone HIV protease inhibitor 1 was identified in our labs, and an X-ray structure of this inhibitor complexed with HIV-2 protease was obtained. This crystal structure was used to develop two strategies for creating derivat

Structure-based design of sulfonamide-substituted non-peptidic HIV protease inhibitors

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