166317-78-8Relevant articles and documents
Structure-activity relationships of the antimalarial agent artemisinin. 3. Total synthesis of (+)-13-carbaartemisinin and related tetra- and tricyclic structures
Avery, Mitchell A.,Fan, Pingchen,Karle, Jean M.,Bonk, Jason D.,Miller, Robert,Goins, D. Keith
, p. 1885 - 1897 (1996)
Provided by total synthesis, endoperoxides 18, 20, and 22 underwent intramolecular oxymercuration-demercuration leading respectively to formation of an isomeric tetracycle, (1aS,3S, 5aS,6R,8aS,9R,125)-10-deoxo-13- carbaartemisinin (19), (+)-10-deoxo-13-ca