166413-85-0

Basic information

• Product Name: N-(1-acetyl-5-indolinyl)-2,2-dimethoxyethylamine
• Synonyms: N-(1-acetyl-5-indolinyl)-2,2-dimethoxyethylamine
• CAS NO: 166413-85-0
• Molecular Weight: 264.324
• Mol File: 166413-85-0.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: N-(1-acetyl-5-indolinyl)-2,2-dimethoxyethylamine(CAS DataBase Reference)
• NIST Chemistry Reference: N-(1-acetyl-5-indolinyl)-2,2-dimethoxyethylamine(166413-85-0)
• EPA Substance Registry System: N-(1-acetyl-5-indolinyl)-2,2-dimethoxyethylamine(166413-85-0)

Safety Data

• Hazardous Substances Data: 166413-85-0(Hazardous Substances Data)

Upstream product

• 51673-84-8 dimethoxyacetaldehyde 
• 4993-96-8 1-(5-aminoindolin-1-yl)ethanone 

Downstream Products

• 158942-04-2 5-methyl-1-(3-pyridylcarbamoyl)-1,2,3,5-tetrahydropyrrolo[2,3-f]indole 

Relevant articles and documents

5-Methyl-1-(3-pyridylcarbamoyl)-1,2,3,5-tetrahydropyrroloindole: A Novel 5-HT2C/5-HT2B Receptor Antagonist with Improved Affinity, Selectivity, and Oral Activity

The preparation of a series of conformationally restricted analogues of indolylurea 1, namely tetrahydropyrroloindoles and tetrahydropyrroloquinolines, is described.The binding affinities of these compounds at 5-HT2A, 5-HT2B, and 5-HT2C receptors were determined.Of these compounds, the 1,2,3,5-tetrahydropyrroloindole derivative, compound 11, was found to have high affinity for the 5-HT2C (pK1 8.0) and 5-HT2B receptors (pA2 8.5), with excellent selectivity over the 5-HT2A and various other receptors (pK1B 8.8), and an in vivo functional model, mCPP-induced hypolocomotion (ID50 5.5 mg/kg po). 11 should therefore be of significant utility as a pharmacological tool to delineate the functional significance of blockade of 5-HT2B and 5-HT2C receptors.