166449-97-4 Usage
Description
(R)-b-(p-chlorophenyl)alanineethylester, also known as (R)-β-(p-chlorophenyl)alanine ethyl ester, is a chemical compound that is an ester of β-(p-chlorophenyl)alanine, an amino acid derived from phenylalanine. (R)-b-(p-chlorophenyl)alanineethylester is characterized by its unique structure and properties, which make it a valuable tool in the development of new drugs and therapies.
Uses
Used in Pharmaceutical Research:
(R)-b-(p-chlorophenyl)alanineethylester is used as a building block in peptide synthesis for the development of new pharmaceuticals. Its unique structure allows for the creation of novel compounds with potential therapeutic applications.
Used in Antidepressant Development:
(R)-b-(p-chlorophenyl)alanineethylester is used as a potential antidepressant agent. Its pharmacological properties are being studied for their ability to alleviate symptoms of depression and improve overall mental health.
Used in Central Nervous System Disorder Treatment:
(R)-b-(p-chlorophenyl)alanineethylester is also being investigated for its potential use in treating central nervous system disorders. Its unique properties may contribute to the development of new therapies for conditions such as anxiety, schizophrenia, and other neurological disorders.
Check Digit Verification of cas no
The CAS Registry Mumber 166449-97-4 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,6,6,4,4 and 9 respectively; the second part has 2 digits, 9 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 166449-97:
(8*1)+(7*6)+(6*6)+(5*4)+(4*4)+(3*9)+(2*9)+(1*7)=174
174 % 10 = 4
So 166449-97-4 is a valid CAS Registry Number.
166449-97-4Relevant articles and documents
Using ionic liquid [EMIM][CH3COO] as an enzyme-'friendly' co-solvent for resolution of amino acids
Zhao, Hua,Jackson, Lee,Song, Zhiyan,Olubajo, Olarongbe
, p. 2491 - 2498 (2007/10/03)
An ionic liquid (IL), 1-ethyl-3-methylimidazolium acetate [EMIM][CH3COO], was used in 0-4.0 M (~60% IL, v/v), as a nonvolatile organic medium for the enzymatic resolution of amino acids. When dl-phenylalanine methyl ester was studied as a model substrate, high enantiomeric excesses (ee) of l-amino acid were obtained in all ionic concentrations; however, lower yields were observed at high IL concentrations. This IL is more enzyme-'friendly' than the hydrophilic organic solvent acetonitrile and those ILs containing chaotropic anions (such as [EMIM][OTs]). Among three proteases and two lipases investigated, lyophilized Bacillus licheniformis protease exhibited the best enantioselectivity and activity. Highly enantioselective resolutions were also produced for several other amino acids in 2.0 M IL. Interestingly, high ee were also found in deuterium oxide (D2O) rather than in ordinary water, and a further enhancement was achieved with the co-existence of [EMIM][CH3COO]. The heavy water effect was explained in terms of protein stabilization by D2O. The secondary structural changes of enzyme in various media were interpreted by the second derivatives of FT-IR spectra.