166582-12-3

Basic information

• Product Name: (S)-3,3-Dimethyl-4-phenyl-azetidin-2-one
• Synonyms: (S)-3,3-Dimethyl-4-phenyl-azetidin-2-one
• CAS NO: 166582-12-3
• Molecular Weight: 175.23
• Mol File: 166582-12-3.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: (S)-3,3-Dimethyl-4-phenyl-azetidin-2-one(CAS DataBase Reference)
• NIST Chemistry Reference: (S)-3,3-Dimethyl-4-phenyl-azetidin-2-one(166582-12-3)
• EPA Substance Registry System: (S)-3,3-Dimethyl-4-phenyl-azetidin-2-one(166582-12-3)

Safety Data

• Hazardous Substances Data: 166582-12-3(Hazardous Substances Data)

Upstream product

• 145774-30-7 1-hydroxymethyl-3,3-dimethyl-4-phenyl-2-azetidinone 
• 7486-93-3 3,3-dimethyl-4-phenylazetidin-2-one 
• 145694-42-4 (S)-(+)-2-hydroxymethyl-3,3-dimethyl-4-phenyl-2-azetidinone 

Relevant articles and documents

Switchover of the diastereoselectivity induced by a simple selection of titanium(IV) halides in the addition reaction of silyl ketene acetals to a chiral imine

Switchover of the diastereoselectivity was recognized by a simple selection of titanium(IV) halides in the reaction of silyl ketene acetal with a chiral imine possessing a derivative of D-(-)-phenylglycine as an auxiliary. TiF4 effected the formation of (3S)-β-amino ester, while TiCl4 gave (3R)-isomer. The β-amino esters thus obtained were convened into the corresponding β-lactams on treatment with Me3Al without loss of the stereochemical integrity.