1666-24-6

Basic information

• Product Name: α-benzoyl-α-(p-tolylsulfonyl)diazomethane
• Synonyms: α-benzoyl-α-(p-tolylsulfonyl)diazomethane
• CAS NO: 1666-24-6
• Molecular Weight: 300.338
• Mol File: 1666-24-6.mol
• Article Data: 6

Chemical Properties

• CAS DataBase Reference: α-benzoyl-α-(p-tolylsulfonyl)diazomethane(CAS DataBase Reference)
• NIST Chemistry Reference: α-benzoyl-α-(p-tolylsulfonyl)diazomethane(1666-24-6)
• EPA Substance Registry System: α-benzoyl-α-(p-tolylsulfonyl)diazomethane(1666-24-6)

Safety Data

• Hazardous Substances Data: 1666-24-6(Hazardous Substances Data)

Upstream product

• 31378-03-7 1-phenyl-2-tosylethanone 
• 938-10-3 phenylsulfonyl azide 
• 70-11-1 α-bromoacetophenone 
• 824-79-3 sodium 4-methylbenzenesulfinate 
• 1538-98-3 p-tosyldiazomethane 
• 98-88-4 benzoyl chloride 

Downstream Products

• 82236-57-5 2-Methyl-5-phenyl-4-(toluene-4-sulfonyl)-oxazole 
• 82236-54-2 Phenyl-(toluene-4-sulfonyl)-acetic acid benzyl ester 
• 19820-36-1 -methyl-ether 
• 31378-03-7 1-phenyl-2-tosylethanone 
• 2943-42-2 di(4-methyl)phenylthiosulfonate 
• 31540-75-7 1-((dichloromethyl)sulfonyl)-4-methylbenzene 
• 460743-34-4 α-chloro-α-(p-tolylsulfonyl)acetophenone 
• 23128-65-6 2-bromo-1-phenyl-2-(toluene-4-sulfonyl)ethanone 
• 901124-40-1 2-iodo-1-phenyl-2-(toluene-4-sulfonyl)ethanone 

Relevant articles and documents

A 'sulfonyl-azide-free' (SAFE) aqueous-phase diazo transfer reaction for parallel and diversity-oriented synthesis

Diazo transfer reactions are notoriously associated with the use of potentially explosive sulfonyl azides. The first 'sulfonyl-azide-free' (SAFE) protocol for producing diazo compounds from their active-methylene precursors via the Regitz diazo transfer reaction was developed and has displayed a remarkable substrate scope. It can be applied to generating arrays of diazo compounds for further evolution via combinatorial chemistry and a range of scaffold-generating transformations.

Copper Triflate Mediated α-Monohalogenation of α-Diazo β-Ketosulfones with Ammonium Halides

Copper triflate mediated α-monohalogenation of α-diazo β-ketosulfones with ammonium halides provides the corresponding α-halo β-ketosulfones. Different metal triflates are investigated for this facile and efficient transformation. A plausible mechanism is proposed.

PREPARATION OF α-DIAZO-β-KETOSULFONES BY DIAZO-TRANSFER REACTION WITH AN IN SITU GENERATED AZIDINIUM SALT. A SAFE AND EFFICIENT PROCEDURE FOR THE DIAZO-TRANSFER REACTION IN NEUTRAL MEDIUM.

An efficinet and mild procedure is described for the preparation of α-diazo-β-ketosulfones using an azidinium salt generated in situ from relatively inexpensive and safe chemicals.The method is equally applicable to other CH2-acidic compounds.