16672-84-7

Basic information

• Product Name: 2-Naphtylmethylphosphonic acid
• Synonyms: 2-Naphtylmethylphosphonic acid
• CAS NO: 16672-84-7
• Molecular Formula: C11H11O3P
• Molecular Weight: 222.177001
• Mol File: 16672-84-7.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 478.0±38.0 °C(Predicted)
• Appearance: /
• Density: 1.397±0.06 g/cm3(Predicted)
• PKA: 2.22±0.10(Predicted)
• CAS DataBase Reference: 2-Naphtylmethylphosphonic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Naphtylmethylphosphonic acid(16672-84-7)
• EPA Substance Registry System: 2-Naphtylmethylphosphonic acid(16672-84-7)

Safety Data

• Hazardous Substances Data: 16672-84-7(Hazardous Substances Data)

Upstream product

• 57277-25-5 (naphthalen-2-ylmethyl)phosphonic acid diethyl ester 
• 939-26-4 2-bromomethylnaphthyl bromide 
• 96314-45-3 (2-naphthalenylmethyl)phosphonic acid dimethyl ester 

Downstream Products

• 278605-34-8 (2S,4S,5R)-2-(2-Naphthylmethyl)-3,4-dimethyl-2-oxo-5-phenyl-1,3,2λ⁵-oxazaphospholidine 
• 278605-31-5 (2R,4S,5R)-2-(2-Naphthylmethyl)-3,4-dimethyl-2-oxo-5-phenyl-1,3,2λ⁵-oxazaphospholidine 
• 278605-37-1 (2R,4S,5R)-2-[(1S)-Fluoro(2-naphthyl)methyl]-3,4-dimethyl-2-oxo-5-phenyl-1,3,2λ⁵-oxazaphospholidine 
• 278605-40-6 (2R,4S,5R)-2-[(1R)-Fluoro(2-naphthyl)methyl]-3,4-dimethyl-2-oxo-5-phenyl-1,3,2λ⁵-oxazaphospholidine 
• 278605-46-2 (2S,4S,5R)-2-[(1S)-Fluoro(2-naphthyl)methyl]-3,4-dimethyl-2-oxo-5-phenyl-1,3,2λ⁵-oxazaphospholidine 
• 278605-43-9 (2S,4S,5R)-2-[(1R)-Fluoro(2-naphthyl)methyl]-3,4-dimethyl-2-oxo-5-phenyl-1,3,2λ⁵-oxazaphospholidine 

Relevant articles and documents

Structural variability of pendant groups within the interlayer region of zirconium arene-phosph(on)ates: Chemical and structural characterization of oxy- And methyl-linked 2-naphthyl phosphonates, and mixed oxy-linked derivatives

Several new zirconium phosphonates incorporating the naphthalene ring and having the general formula Zr(O3PR)1(O3PR′)1 [R and R′ = -CH2C10H7, -OC10H7, -CH3, -OC2H5, -OH] have been synthesized. These materials were chemically characterized using thermal gravimetric analysis (percentage of organic content), infrared spectroscopy (presence of the desired organic functional groups), and solid-state 31P NMR (phosphorus environments), while the structural parameters were determined using X-ray powder diffraction (interlayer d spacings). The two new zirconium bis(phosphonates), Zr(O3PC10H7)2 and Zr(O3PCH2C10H7)2, were found to have d spacings of 19.6 and 20.0 ?, respectively. Three of the four zirconium mixed phosphonates examined are found to be single-phase structures with random mixtures of the organic moieties within the interlayer, and possess d spacings (14.3, 15.3, and 16.1 ?) that are between those of the two parent zirconium bis(phosphonates). The fourth is found to be a staged or segregated structure and possesses a d spacing that is approximately a sum of the two parent zirconium bis(phosphonates), with a d spacing of 28.2 ?. Solid-state 31P NMR of Zr(O3PCH2C10H7)2 revealed the presence of two isotropic resonances, which is interpreted in terms of two distinct, "locked-in" conformations of the -CH2C10H7 group. The experimental d spacings of the zirconium bis(phosphonates) correlate well with a simple predictive model based on the effective length and predominant conformation of the organic functional group.

Arylmethylphosphonates and phosphonic acids useful as anti-inflammatory agents

This invention provides a new use of acids, esters, and salts of arylmethylphosphonates of Formula I, STR1 or phosphonic acid derivatives of Formula II STR2 as anti-inflammatory and anti-arthritic agents. Representative compounds include 4-dodecyloxybenzylphosphonic acid dimethyl ester, (2-naphthalenylmethyl)phosphonic acid dimethyl ester, and ([1,1 '-biphenyl]-2-ylmethyl)phosphonic acid dimethyl ester. The invention also provides novel acids, esters, and salts of arylmethylphosphonic acid, phosphonic acid and derivatives.