166739-13-5

Basic information

• Product Name: Glycine, N-cyclohexyl-N-[(1,1-dimethylethoxy)carbonyl]-
• Synonyms: N-Boc-N-cyclohexyl-glycine;n-(Tert-butoxycarbonyl)-N-cyclohexylglycine;2-{[(tert-butoxy)carbonyl](cyclohexyl)amino}acetic acid;Glycine, N-cyclohexyl-N-[(1,1-dimethylethoxy)carbonyl]-;2-[cyclohexyl-[(2-methylpropan-2-yl)oxycarbonyl]amino]acetic acid
• CAS NO: 166739-13-5
• Molecular Formula: C₁₃H₂₃NO₄
• Molecular Weight: 257.33
• Mol File: 166739-13-5.mol
• Article Data: 12

Chemical Properties

• Boiling Point: 379.0±21.0 °C(Predicted)
• Appearance: /
• Density: 1.11±0.1 g/cm3(Predicted)
• PKA: 4.01±0.10(Predicted)
• CAS DataBase Reference: Glycine, N-cyclohexyl-N-[(1,1-dimethylethoxy)carbonyl]-(CAS DataBase Reference)
• NIST Chemistry Reference: Glycine, N-cyclohexyl-N-[(1,1-dimethylethoxy)carbonyl]-(166739-13-5)
• EPA Substance Registry System: Glycine, N-cyclohexyl-N-[(1,1-dimethylethoxy)carbonyl]-(166739-13-5)

Safety Data

• Hazardous Substances Data: 166739-13-5(Hazardous Substances Data)

Upstream product

• 172834-20-7 Boc-N-cyclohexylglycine benzyl ester 
• 3712-40-1 tert-butyl cyclohexylcarbamate 
• 24424-99-5 di-tert-butyl dicarbonate 
• 65940-30-9 N-cyclohexylglycine benzyl ester 
• 108-91-8 cyclohexylamine 
• 150806-61-4 N-t-butoxycarbonyl L-phenylglycine 
• 37883-45-7 ethyl N-cyclohexylglycinate 

Downstream Products

• 807612-20-0 {2-[2-(benzothiazole-2-carbonyl)-azetidin-1-yl]-2-oxo-ethyl}-cyclohexyl-carbamic acid tert-butyl ester 
• 807612-10-8 {2-[2-(benzothiazole-2-carbonyl)-pyrrolidin-1-yl]-2-oxo-ethyl}-cyclohexyl-carbamic acid tert-butyl ester 
• 753501-09-6 cyclohexyl-(2-oxo-2-piperidin-1-yl-ethyl)-carbamic acid tert-butyl ester 
• 777946-66-4 2-cyclohexylamino-1-pyrrolidin-1-yl-ethanethione 
• 1312023-04-3 tert-butyl-1-cyclohexyl-2-hydroxyethylcarbamate 
• 479028-32-5 BOC-CYCLOHEXYLGLYCINAL 

Relevant articles and documents

Alkali-metal hexamethyldisilazide initiated polymerization on alpha-amino acid N-substituted N-carboxyanhydrides for facile polypeptoid synthesis

Polypeptoids have been explored as mimics of polypeptides, owing to polypeptoids’ superior stability upon proteolysis. Polypeptoids can be synthesized from one-pot ring-opening polymerization of amino acid N-substituted N-carboxyanhydrides (NNCAs). However, the speed of polymerization of NNCAs can be very slow, especially for NNCAs bearing a bulky N-substitution group. This hindered the exploration on polypeptoids with more diverse structures and functions. Therefore, it is in great need to develop advanced strategies that can accelerate the polymerization on inactive NNCAs. Hereby, we report that lithium/sodium/potassium hexamethyldisilazide (Li/Na/KHMDS) initiates a substantially faster polymerization on NNCAs than do commonly used amine initiators, especially for NNCAs with bulky N-substitution group. This fast NNCA polymerization will increase the structure diversity and application of polypeptoids as synthetic mimics of polypeptides.

DIPEPTIDYL PEPTIDASE INHIBITORS

The present invention relates to novel inhibitors of serine type peptidases in general and of serine type dipeptidyl peptidases in particular. The present invention further relates to the use of the dipeptidyl peptidase inhibitors for selective inhibition

ANTITHROMBOTIC AGENTS

This invention relates to thrombin inhibiting compounds having the FormulaIX--Y--NH--(CH 2) r--G I where X, Y, r and G have the values defined in the description, as well as pharmaceutical formulations containing those compounds and methods of their use as thrombin inhibitors, coagulation inhibitors, and thromboembolic disorder agents.