1668-42-4

Basic information

• Product Name: 1-[4-(3-chlorophenyl)piperazin-1-yl]-3-phenoxypropan-2-ol
• Synonyms: 1-[4-(3-Chlorophenyl)piperazin-1-yl]-3-phenoxypropan-2-ol; 1-piperazineethanol, 4-(3-chlorophenyl)-alpha-(phenoxymethyl)-
• CAS NO: 1668-42-4
• Molecular Formula: C₁₉H₂₃ClN₂O₂
• Molecular Weight: 346.8511
• Mol File: 1668-42-4.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 523.1°C at 760 mmHg
• Flash Point: 270.2°C
• Density: 1.216g/cm³
• Vapor Pressure: 9.02E-12mmHg at 25°C
• Refractive Index: 1.593
• CAS DataBase Reference: 1-[4-(3-chlorophenyl)piperazin-1-yl]-3-phenoxypropan-2-ol(CAS DataBase Reference)
• NIST Chemistry Reference: 1-[4-(3-chlorophenyl)piperazin-1-yl]-3-phenoxypropan-2-ol(1668-42-4)
• EPA Substance Registry System: 1-[4-(3-chlorophenyl)piperazin-1-yl]-3-phenoxypropan-2-ol(1668-42-4)

Safety Data

• Hazardous Substances Data: 1668-42-4(Hazardous Substances Data)

Usage

Chemical Class

Serotonin Antagonist and Reuptake Inhibitor (SARI)

Primary Use

Antidepressant and anxiolytic medication

Mechanism of Action

Inhibits the reuptake of serotonin and blocks serotonin receptors

Indications

Major depressive disorder, anxiety disorders, and insomnia

Administration

Orally, in the form of tablets or capsules

Sedative Effects

Yes, useful for treating insomnia

Side Effects

Drowsiness, dizziness, and nausea

Importance

Potential therapeutic benefits for various mental health conditions

Upstream product

• 122-60-1 Phenyl glycidyl ether 
• 6640-24-0 N-(m-chlorophenyl)piperazine 

Relevant articles and documents

3-Tertiary amino-1-aryloxy- or aryl-propanes and -propan -2-ols and some related compounds

The synthesis and pharmacological activity of some 3 tertiary amino 1 aryloxy or 1 aryl, 1 thiophenoxy and 1 anilino propan 2 ols and propanes, particularly those derived from N phenylpiperazines are described. Effect of substituents (nature/position) on the phenyl ring, the phenoxy ring as well as alteration in the hydroxylic function vis a vis the structure activity relationships (SAR) are discussed. In general, the 1 aryloxy compounds have hypotensive activity this being more pronounced in those carrying an o substituent on the phenyl ring, while m and p substituted derivatives have their effect primarily on the CNS. Variations in the phenoxy moiety do not significantly alter the intrinsic activity. The 1 aryl compounds, on the other hand, have significant CNS activity, which is markedly affected by the substituents on the 1 aryl residue.