16681-78-0

Basic information

• Product Name: 2H-Tetrazole, 2-methyl-
• Synonyms: 2H-Tetrazole, 2-methyl-;2-Methyl-2H-tetrazole
• CAS NO: 16681-78-0
• Molecular Formula: C₂H₄N₄
• Molecular Weight: 84.08
• Mol File: 16681-78-0.mol
• Article Data: 10

Chemical Properties

• Boiling Point: 171.3 °C at 760 mmHg
• Flash Point: 57.4 °C
• Appearance: /
• Density: 1.4 g/cm³
• Vapor Pressure: 1.41mmHg at 25°C
• Refractive Index: 1.664
• CAS DataBase Reference: 2H-Tetrazole, 2-methyl-(CAS DataBase Reference)
• NIST Chemistry Reference: 2H-Tetrazole, 2-methyl-(16681-78-0)
• EPA Substance Registry System: 2H-Tetrazole, 2-methyl-(16681-78-0)

Safety Data

• Hazardous Substances Data: 16681-78-0(Hazardous Substances Data)

Usage

General Description

2H-Tetrazole, 2-methyl- is a chemical compound with the molecular formula C2H4N4. It is a member of the tetrazole family, which is characterized by a five-membered ring containing four nitrogen atoms and one carbon atom. This particular compound is a methyl derivative of 2H-tetrazole and is used in pharmaceuticals, agrochemicals, and energetic materials. It has been studied for its potential applications in drugs for cardiovascular diseases, central nervous system disorders, and cancer treatment. Additionally, 2-methyl-2H-tetrazole can be used as a building block in the synthesis of various organic compounds and may have potential industrial and research applications.

InChI:InChI=1/C2H4N4/c1-6-4-2-3-5-6/h2H,1H3

Upstream product

• 288-94-8 1H-tetrazole 
• 77-78-1 dimethyl sulfate 
• 74-88-4 methyl iodide 
• 13175-00-3 2-methyl-2H-1,2,3,4-tetrazole-5-carboxylic acid 
• 288-94-8 2H-tetrazole 

Downstream Products

• 107403-54-3 3-Methyl-1-[2-(4-nitro-phenyl)-2-oxo-ethyl]-3H-tetrazol-1-ium; bromide 
• 107403-52-1 3-Methyl-1-(2-oxo-2-phenyl-ethyl)-3H-tetrazol-1-ium; bromide 
• 107403-53-2 1-[2-(4-Bromo-phenyl)-2-oxo-ethyl]-3-methyl-3H-tetrazol-1-ium; bromide 
• 1025840-65-6 [(S)-2-Methyl-1-(2-methyl-2H-tetrazole-5-carbonyl)-propyl]-carbamic acid benzyl ester 

Relevant articles and documents

Synthesis and structure of 1-tert-butyl-3-R-tetrazolium salts

An effective method was developed for the synthesis of 1,3-disubstituted tetrazolium salts by the quaternization of 2-monosubstituted tetrazoles, including functionally substituted compounds, with tert-butanol in 72% perchloric acid. An X-ray diffraction

Coordination chemistry with 1-methyl-5: H -tetrazole: Cocrystallization, laser-ignition, lead-free primary explosives-one ligand, three goals

The synthesis and characterization of 1-methyl-5H-tetrazole (1, MTZ) from 1,5H-tetrazole and methyl iodide is achieved. This neutral ligand was evaluated for its use in energetic transition metal complexes. The formation of complexes is a valuable concept because of their easy synthesis and the large number of possible combinations: (i) metal, (ii) ligand, and (iii) anion. A series of 31 new complexes based on MTZ as the ligand was prepared in order to tune their optical properties and sensitivity values by using seven different metals (Mn2+, Fe2+, Co2+, Ni2+, Cu2+, Zn2+, and Ag+) and six different anions (chloride, nitrate, perchlorate, cyanodinitromethanide, picrate, and styphnate). This variation allows tailoring of the energetic properties of the desired molecule toward e.g. suitable primary explosives or laser-ignitable materials. Obtained compounds were characterized by low temperature single crystal X-ray diffraction, IR spectroscopy, elemental analysis and thermal analysis (DTA, DSC and TGA). The sensitivities toward external stimuli (impact, friction and electrostatic discharge) were determined according to the Bundesamt für Materialforschung und -prüfung (BAM) standard methods. These complexes have been characterized in laser ignition experiments and as new primary explosives. UV-vis measurements of selected complexes were carried out to get a possible insight into the laser initiation mechanism. For the first time a large number of compounds with sensitivities ranging from insensitive to very sensitive were synthesized to give a wide range of new materials for different possible applications.

Antibacterial compounds with improved pharmacokinetic profiles

Antibacterial compounds with improved pharmacokinetic profiles having formula (I) and salts, prodrugs, and salts of prodrugs thereof, processes for making the compounds and intermediates used in the processes, compositions containing the compounds, and methods for prophylaxis and treatment of bacterial infections using the compounds are disclosed.