16689-13-7

Basic information

• Product Name: L-Histidine, N-[N-[(phenylmethoxy)carbonyl]-L-phenylalanyl]-, methyl ester
• CAS NO: 16689-13-7
• Molecular Formula: C24H26N4O5
• Molecular Weight: 450.494
• Mol File: 16689-13-7.mol
• Article Data: 7

Chemical Properties

• CAS DataBase Reference: L-Histidine, N-[N-[(phenylmethoxy)carbonyl]-L-phenylalanyl]-, methyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: L-Histidine, N-[N-[(phenylmethoxy)carbonyl]-L-phenylalanyl]-, methyl ester(16689-13-7)
• EPA Substance Registry System: L-Histidine, N-[N-[(phenylmethoxy)carbonyl]-L-phenylalanyl]-, methyl ester(16689-13-7)

Safety Data

• Hazardous Substances Data: 16689-13-7(Hazardous Substances Data)

Upstream product

• 1161-13-3 N-Cbz-L-Phe 
• 7389-87-9 L-histidine methyl ester dihydrochloride 
• 1161-13-3 N-(Benzyloxycarbonyl)-L-phenylalanine 
• 7389-87-9 (S)-histidine methyl ester dihydrochloride 
• 3588-57-6 Z-DL-Phe-OH 
• 4467-54-3 l-histidine methyl ester dihydrochloride 
• 1499-46-3 L-Histidine methyl ester 
• 2578-84-9 N-benzyloxycarbonyl-L-phenylalanine p-nitrophenyl ester 

Downstream Products

• 90703-14-3 N-dodecanoyl-L-phenylalanyl-L-histidine 
• 79416-20-9 N-dodecanoyl-L-phenylalanyl-L-histidine methyl ester 
• 123580-40-5 N-acetyl-L-phenylalanyl-L-histidine 
• 133230-90-7 N-acetyl-L-phenylalanyl-L-histidine methyl ester 
• 56586-95-9 Cyclo(histidylphenylalanine) 
• 109539-11-9 ZPheHisThrPheProOBzl 
• 53438-59-8 HPheHisThrPheProOH 
• 66253-25-6 ZPheHisN₃ 
• 109603-66-9 ZAsnLys(Boc)PheHisThrPheProOH*HCl 
• 120609-53-2 Z-Gly-L-Phe-L-His-OMe 
• 120609-80-5 (S)-2-[(S)-2-(2-Benzyloxycarbonylamino-acetylamino)-3-phenyl-propionylamino]-3-(1H-imidazol-4-yl)-propionic acid 
• 20806-35-3 ZPheHisN₂H₃ 
• 18779-16-3 L-phenylalanyl-L-histidine methyl ester dihydrobromide 
• 20806-38-6 N-(Benzyloxycarbonyl-L-phenylalanyl)-L-histidine 

Relevant articles and documents

Design, synthesis, and application of enantioselective coupling reagent with a traceless chiral auxiliary

(Chemical Equation Presented) Stable chiral N-triazinylbrucinium tetrafluoroborate enantioselectively activates racemic carboxylic acids yielding enantiomerically enriched amides, esters, and dipeptides with er from 8:92 to 0.5:99.5. Due to the departure

Thermodynamic and (1)H NMR Study of Proton Complex Formation of Histidine-containing Cyclodipeptides in Aqueous Solution

A thermodynamic and (1)H NMR study of proton complex formation in aqueous solution of some L-histidine-containing cyclic L-dipeptides has been carried out.The enthalpic and entropic changes associated with protonation of the cyclodipeptides, obtained by potentiometric and calorimetric measurements, together with the (1)H NMR data and NOESY experiments, enable the role played by non-covalent interactions in proton complex formation to be assessed.In addition, a comparison with c(Gly-His) permits the influence of side-chain residues on the conformation of protonated species to be observed.

The Cyclic Dipeptide cyclo as a Catalyst for Asymmetric Addition of Hydrogen Cyanide to Aldehydes

cyclo (cyclo, 1) catalyzes the addition of hydrogen cyanide to benzaldehyde in toluene at -20 deg C to afford (R)-mandelonitrile with enantiomeric excess of 97 percent in high yield. cyclo gives (S)-mandelonitrile. cyclo (1) exhibits a broad substrate specificity, and a variety of aldehydes (3a-r) such as m-methoxybenzaldehyde (3c), 6-methoxy-2-naphthaldehyde (3k), and isobutyraldehyde (3o) similarly afforded the corresponding cyanohydrins with high enantiopurities (97 percent ee for 3c, 93 percent ee for 3k, 71 percent ee for 3o). (R)-Mandelonitrile thus obtained was successfully converted to various chiral synthons such as mandelic acid (7), methyl mandelate (8), and 2-amino-1-phenylethanol (9) without any racemization.