166942-24-1Relevant articles and documents
New silane reduction of aromatic ketones mediated by titanium tetrachloride : A synthesis of γ- and δ-aryl substituted amino acids
Yato, Michihisa,Homma, Koichi,Ishida, Akihiko
, p. 233 - 254 (2007/10/03)
Several N-protected 4-aryl-2-aminobutanoic acids (γ-aryl substituted amino acids ; 7a-f) and N-protected 5-aryl-2-aminopentanoic acids (δ-aryl substituted amino acids ; 8a,b and d) were prepared in good yields by reduction of the corresponding aromatic or heteroaromatic ketones (3 and 4) with triethylsilane (Et3SiH) or dimethylphenylsilane (PhMe2SiH) in the presence of titanium tetrachloride (TiCl4), respectively. The reduction proceeded without racemization and was successfully applied to the synthesis of optically active γ-and δ-aryl substituted amino acids (14a and 15a).