167155-56-8

Basic information

• Product Name: 4-(CHLOROMETHYL)-2-(4-METHOXYPHENYL)-1,3-OXAZOLE
• Synonyms: 4-(CHLOROMETHYL)-2-(4-METHOXYPHENYL)-1,3-OXAZOLE
• CAS NO: 167155-56-8
• Molecular Formula: C₁₁H₁₀ClNO₂
• Molecular Weight: 223.6556
• Mol File: 167155-56-8.mol
• Article Data: 5

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 4-(CHLOROMETHYL)-2-(4-METHOXYPHENYL)-1,3-OXAZOLE(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(CHLOROMETHYL)-2-(4-METHOXYPHENYL)-1,3-OXAZOLE(167155-56-8)
• EPA Substance Registry System: 4-(CHLOROMETHYL)-2-(4-METHOXYPHENYL)-1,3-OXAZOLE(167155-56-8)

Safety Data

• Hazardous Substances Data: 167155-56-8(Hazardous Substances Data)

Upstream product

• 3424-93-9 4-methoxyphenylacetamide 
• 534-07-6 1,3-Dichloroacetone 
• 123-11-5 4-methoxy-benzaldehyde 
• 885273-76-7 2-(4-methoxyphenyl)-4-hydroxymethyloxazole 
• 154405-98-8 methyl 2-(4-methoxyphenyl)-1,3-oxazole-4-carboxylate 

Downstream Products

• 851392-16-0 1-[2-(4-methoxy-phenyl)-oxazol-4-ylmethyl]-1H-[1,2,3]triazole 
• 885272-87-7 C₁₁H₁₂N₂O₂ 

Relevant articles and documents

Design, Synthesis and Biological Evaluation of N-((2-phenyloxazol-4-yl)methyl) Pyrimidine Carboxamide Derivatives as Potential Fungicidal Agents

Twelve N-((2-phenyloxazol-4-yl)methyl) pyrimidine carboxamide derivatives were designed, synthesized, and characterized by 1H NMR, 13C NMR, and HRMS. The fungicidal activities of these new compounds against Sclerotinia sclerotiorum, Botrytis cinereal, and Colletotrichum fragariae were evaluated. The results indicated that compounds 5b, 5f, and 5g displayed potential fungicidal activities against tested fungi, especially 5f exhibited IC50 value of 28.9 mg/L against S. sclerotiorum. Moreover, the compounds 5f and 5g showed IC50 values of 54.8 mg/L and 62.2 mg/L against C. fragariae respectively, which shows that they were more active than the commercial fungicide hymexazol. The superficial structure-activity relationships were discussed, which may be of benefit for the development of fungicides and discovery of novel fungicides.

Discovery of the disubstituted oxazole analogues as a novel class anti-tuberculotic agents against MDR- and XDR-MTB

A high-throughput screening effort on 45,000 compounds resulted in the discovery of a disubstituted oxazole as a new structural class inhibitor of Mycobacterium tuberculosis (Mtb). In order to improve the activity and investigate the SAR of this scaffold, a series of disubstituted azole analogues have been designed and synthesized. The newly synthesized compounds 1a-y were evaluated for their in vitro anti-TB activity versus replicating, multi- and extensive drug resistant Mtb strains. All the compounds, except 1o, 1p and 1q, showed potent anti-TB activity with MIC of 1-64 mg/L. The test of broad spectrum panel revealed that this series are specific to Mtb. The cytotoxicity assessment indicated that the compounds were not cytotoxic against HEK 293 cells. The compounds could have a novel mechanism to anti-Mtb as they can inhibit drug sensitive and drug resistant Mtb.

1-′(E)-2-(PHENYL) ETHENYL-4-(ARYLALKOXY)-OXAZOLE OR - THIAZOLE COMPOUNDS AS HER-2 TYROSINE KINASES INHIBITORS AND THEIR USE IN THE TREATMENT OF CANCER

Objects of the present invention are the compounds of formula (I), their pharmaceutically acceptable salts, enantiomeric forms thereof, diastereoisomers and racemates, the preparation of the above-mentioned compounds, medicaments containing them and their