167156-20-9Relevant articles and documents
Copper-catalyzed formal transfer hydrogenation/deuteration of aryl alkynes
Sloane, Samantha E.,Reyes, Albert,Vang, Zoua Pa,Li, Lingzi,Behlow, Kiera T.,Clark, Joseph R.
supporting information, p. 9139 - 9144 (2020/11/30)
A copper-catalyzed reduction of alkynes to alkanes and deuterated alkanes is described under transfer hydrogenation and transfer deuteration conditions. Commercially available alcohols and silanes are used interchangeably with their deuterated analogues as the hydrogen or deuterium sources. Transfer deuteration of terminal and internal aryl alkynes occurs with high levels of deuterium incorporation. Alkyne-containing complex natural product analogues undergo transfer hydrogenation and transfer deuteration selectively, in high yield. Mechanistic experiments support the reaction occurring through a cis-alkene intermediate and demonstrate the possibility for a regioselective alkyne transfer hydrodeuteration reaction.
Method for synthesizing benzsulfamide compound from benzene sulfonyl chloride compound and triethylamine without metal catalysis
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Paragraph 0018-0019, (2019/02/04)
The invention relates to a method for synthesizing a benzsulfamide compound from a benzene sulfonyl chloride compound and triethylamine without metal catalysis. The benzsulfamide compound is generatedby adopting the benzene sulfonyl chloride compound and
3-Acyl-2,6-diaminopyridines as cyclin-dependent kinase inhibitors: Synthesis and biological evaluation
Lin, Ronghui,Lu, Yanhua,Wetter, Steven K.,Connolly, Peter J.,Turchi, Ignatius J.,Murray, William V.,Emanuel, Stuart L.,Gruninger, Robert H.,Fuentes-Pesquera, Angel R.,Adams, Mary,Pandey, Niranjan,Moreno-Mazza, Sandra,Middleton, Steven A.,Jolliffe, Linda K.
, p. 2221 - 2224 (2007/10/03)
A novel series of 2,6-diamino-3-acylpyridines were designed and synthesized as cyclin-dependent kinase (CDK) inhibitors. The representative compounds 2r and 11 showed potent CDK1 and CDK2 inhibitory activities and inhibited cellular proliferation in HeLa,