167167-93-3

Basic information

• Product Name: ethyl 2,3-bis(3,4-dimethoxyphenyl)-3-oxopropanoate
• Synonyms: ethyl 2,3-bis(3,4-dimethoxyphenyl)-3-oxopropanoate
• CAS NO: 167167-93-3
• Molecular Weight: 388.417
• Mol File: 167167-93-3.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: ethyl 2,3-bis(3,4-dimethoxyphenyl)-3-oxopropanoate(CAS DataBase Reference)
• NIST Chemistry Reference: ethyl 2,3-bis(3,4-dimethoxyphenyl)-3-oxopropanoate(167167-93-3)
• EPA Substance Registry System: ethyl 2,3-bis(3,4-dimethoxyphenyl)-3-oxopropanoate(167167-93-3)

Safety Data

• Hazardous Substances Data: 167167-93-3(Hazardous Substances Data)

Upstream product

• 18066-68-7 ethyl 3,4-dimethoxyphenylacetate 
• 3943-77-9 ethyl veratrate 

Relevant articles and documents

Synthesis of DL-threo-3-(1-fluoro-1-methylethyl)- and DL-threo-3-(1,1-difluoroethyl)malic acids. Machanistic studies of 3-isopropylmalate dehydrogenase

For both mechanistic studies and the development of novel inhibitors of 3-isopropylmalate dehydrogenase enzyme (IPMDH), which is involved in the rate-determining step in the biosynthesis pathway of the essential amino acid L-leucine, (2R*,3S*)-3-(1-fluoro-1-methylethyl)- and (2R*,3S*)-3-(1,1-difluoroethyl)malic acids (F-IPM and F2-EM) were designed based on the concept of mechanism-based inhibition, and the reaction kinetics with these fluorinated substrates were analysed.The reaction of F-IPM with IPMDH was studied by NMR spectroscopy and product isolation.F-IPM underwent, after the normal enzyme reaction, the expected additional elimination reaction to afford an α,β-unsaturated carbonyl product, which turned out not to participate in any covalen-bond-forming reaction.The conformation of the reaction intermediate during the IPMDH reaction and the functional-group arrangement in the active site of IPMDH are discussed.