1673-62-7Relevant articles and documents
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Hopff et al.
, p. 135,138 (1960)
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Synthesis of annelated imidazoles and benzimidazoles
McClure, James R.,Custer, John H.,Schwarz, H. Dean,Lill, Deborah A.
, p. 710 - 712 (2007/10/03)
A variety of fused ring imidazole or benzimidazole derivatives were prepared through two successive condensations of a dihalide with 4,5- diphenylimidazole or benzimidazole. The 2-methyl substituted derivatives of 4,5-diphenylimidazole or benzimidazole were also used. The size of the annelated ring, which is dependent on the dihalide used, can be varied from five to seven atoms. Initially, N-alkylhalo derivatives were prepared by condensation of the heterocyclic starting materials with a dihalide. Ring closure was then effected through intramolecular condensation of a carbanion derived from the 2-position or the 2-methyl group of the parent heterocyclic ring with the N-alkylhalo moiety.
