16733-85-0

Basic information

• Product Name: 1,3-Thiazole-2-carboxamide
• Synonyms: 1,3-Thiazole-2-carboxamide;2-Thiazolecarboxamide;Thiazole-2-carboxaMide
• CAS NO: 16733-85-0
• Molecular Formula: C4H4N2OS
• Molecular Weight: 128.15
• Mol File: 16733-85-0.mol
• Article Data: 4

Chemical Properties

• Melting Point: 118 °C
• Boiling Point: 283.76°C at 760 mmHg
• Flash Point: 125.414°C
• Appearance: /
• Density: 1.411g/cm³
• Vapor Pressure: 0.003mmHg at 25°C
• Refractive Index: 1.614
• Storage Temp.: 2-8°C
• PKA: 14.92±0.50(Predicted)
• CAS DataBase Reference: 1,3-Thiazole-2-carboxamide(CAS DataBase Reference)
• NIST Chemistry Reference: 1,3-Thiazole-2-carboxamide(16733-85-0)
• EPA Substance Registry System: 1,3-Thiazole-2-carboxamide(16733-85-0)

Safety Data

• Hazardous Substances Data: 16733-85-0(Hazardous Substances Data)

Usage

General Description

1,3-Thiazole-2-carboxamide is a chemical compound with the molecular formula C4H3N3OS. It is a heterocyclic compound containing a thiazole ring and a carboxamide functional group. 1,3-Thiazole-2-carboxamide has various biological activities, including antimicrobial, antiviral, and antitumor properties. It is commonly used as a building block in the synthesis of pharmaceuticals and agrochemicals. Additionally, 1,3-Thiazole-2-carboxamide has been studied for its potential as a therapeutic agent for the treatment of various diseases, including cancer and infectious diseases. Overall, this compound has versatile applications in the fields of medicine, agriculture, and chemical research.

InChI:InChI=1/C4H4N2OS/c5-3(7)4-6-1-2-8-4/h1-2H,(H2,5,7)

Upstream product

• 14527-42-5 thiazole-2-carboxylic acid ethyl ester 
• 14190-59-1 1,3-thiazole-2-carboxylic acid 
• 16733-90-7 1,3-thiazole-2-carbohydrazide 
• 3034-53-5 2-bromo-1,3-thiazole 
• 3019-71-4 Trichloroacetyl isocyanate 
• 3581-87-1 2-methylthiazole 
• 1452-16-0 thiazole-2-carbonitrile 

Downstream Products

• 1452-16-0 thiazole-2-carbonitrile 
• 10200-59-6 Thiazole-2-carbaldehyde 
• 14542-12-2 (1,3-thiazol-2-yl)methanol 

Relevant articles and documents

Trash to treasure: Eco-friendly and practical synthesis of amides by nitriles hydrolysis in WepPA

The hydration of nitriles to amides in a water extract of pomelo peel ash (WEPPA) was realized with moderate to excellent yields without using external transition metals, bases or organic solvents. This reaction features a broad substrate scope, wide functional group tolerance, prominent chemoselectivity, and good reusability. Notably, a magnification experiment in this bio-based solvent at 100 mmol further demonstrated its practicability.

Preparation of primary amides from functionalized organozinc halides

Organozinc halides, which are prepared either by direct zinc insertion or halogen-magnesium exchange and subsequent transmetalation with ZnCl2, react smoothly with commercially available trichloroacetyl isocyanate to give, after hydrolysis, the corresponding primary amides. This method is compatible with a variety of functional groups such as an ester or a cyano group. Also heterocyclic-, alkenyl, and acetylenic zinc reagents are converted to the corresponding primary amides under these conditions.