16738-20-8

Basic information

• Product Name: 1-(2,4-DIMETHYLPHENYL)-2-THIOUREA
• Synonyms: (2,4-xylyl)thiourea;2,4-xylylthiourea;2-thio-1-(2,4-xylyl)-ure;2-thio-1-(2,4-xylyl)urea;2,4-DIMETHYLPHENYLTHIOUREA;1-(2,4-DIMETHYLPHENYL)-2-THIOUREA;AKOS BBS-00000747;1-(2,4-Dimethylphenyl)thiourea
• CAS NO: 16738-20-8
• Molecular Formula: C₉H₁₂N₂S
• Molecular Weight: 180.27
• EINECS: -0
• Mol File: 16738-20-8.mol
• Article Data: 18

Chemical Properties

• Melting Point: 177-179°C
• Boiling Point: 290.7°Cat760mmHg
• Flash Point: 129.6°C
• Appearance: /
• Density: 1.2g/cm³
• Vapor Pressure: 0.00203mmHg at 25°C
• Refractive Index: 1.674
• PKA: 13.40±0.70(Predicted)
• BRN: 2639862
• CAS DataBase Reference: 1-(2,4-DIMETHYLPHENYL)-2-THIOUREA(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(2,4-DIMETHYLPHENYL)-2-THIOUREA(16738-20-8)
• EPA Substance Registry System: 1-(2,4-DIMETHYLPHENYL)-2-THIOUREA(16738-20-8)

Safety Data

• Statements: 25
• Safety Statements: 22-36/37-45
• RIDADR: 2811
• RTECS: YU3675000
• HazardClass: 6.1
• PackingGroup: II
• Hazardous Substances Data: 16738-20-8(Hazardous Substances Data)

Usage

Uses

(2,4-Dimethylphenyl)thiourea

InChI:InChI=1/C9H12N2S/c1-6-3-4-8(7(2)5-6)11-9(10)12/h3-5H,1-2H3,(H3,10,11,12)

Upstream product

• 39842-01-8 2,4-dimethylphenylisothiocyanate 
• 1147550-11-5 ammonium thiocyanate 
• 21436-96-4 2,4-xylidine hydrochloride 
• 83697-77-2 N-(2,4-dimethylphenyl)-N′-benzoylthiourea 
• 95-68-1 2,4-Xylidine 
• 56615-73-7 C₆H₁₅N*C₉H₁₁NS₂ 

Downstream Products

• 64036-71-1 2-amino-4,6-dimethylbenzothiazole 
• 500586-75-4 1-(2,4-dimethylphenyl)-5-amino-1H-tetrazole 
• 71232-25-2 2,4-dimethylphenyl cyanamide 
• 154371-23-0 2-(2,4-Dimethyl-phenylamino)-1-thia-3,9,10-triaza-anthracen-4-one 
• 94646-85-2 1-(2,4-Dimethyl-phenyl)-2-methyl-isothiourea; hydriodide 
• 133890-02-5 4,6-diamino-1-(2,4-dimethylphenyl)-2(1H)-pyrimidinethione 
• 119155-48-5 N-(2,4-Dimethyl-phenyl)-pyrrolidine-1-carboxamidine; hydriodide 
• 119155-49-6 N-(2,4-Dimethyl-phenyl)-morpholine-4-carboxamidine; hydriodide 
• 71018-87-6 1-(2,4-dimethylphenyl)-5-methyl-tetrahydro-s-triazin-2[1H]-thione 
• 1267448-30-5 6,8-dimethyl-4-phenyl-2H-pyrimido[2,1-b]benzothiazol-2-one 
• 2295-31-0 thiazoline-2,4-dione 
• 2990-02-5 1-(2,4-dimethylphenyl)urea 

Relevant articles and documents

Iron-mediated desulphurization approach: synthesis of cyanamides and their conversions

The iron-mediated efficient multi-component method has been demonstrated for the synthesis of substituted cyanamides from isothiocyanates under mild reaction conditions. Subsequent nucleophilic addition and desulfurization are involved in this proposed synthetic methodology. All the reactions are rapid, facile, and accomplished at room temperature. A variety of substrates readily underwent the optimized reaction conditions to provide their respective target products in good to excellent yields. Furthermore, we have confirmed that no other by-products could be identified during our experimental reaction process. Graphical abstract: Iron-mediated efficient multi-component method has been demonstrated for the synthesis of substituted cyanamides from isothiocyanates under mild reaction conditions. Subsequent nucleophilic addition and desulfurization are involved in this proposed synthetic methodology.[Figure not available: see fulltext.].

The in vivo antinociceptive and μ-opioid receptor activating effects of the combination of N-phenyl-2′,4′-dimethyl-4,5′-bi-1,3-thiazol-2-amines and naloxone

Morphine is widely used for the treatment of severe pain. This analgesic effect is mediated principally by the activation of μ-opioid receptors (MOR). However, prolonged activation of MOR also results in tolerance, dependence, addiction, constipation, nau

Fe3O4@SiO2 nanoparticle supported ionic liquid for green synthesis of antibacterially active 1-carbamoyl-1-phenylureas in water

In the present work, we have designed a novel, heterogeneous and recyclable magnetic Br?nsted acidic ionic liquid based on 5-phenyl-1H-tetrazole. The {Fe3O4@SiO2@CH2)35-phenyl-1H-tetrazole-SO3H/Cl} ([FSTet-SO3H]Cl) was prepared via the immobilization of 5-phenyl-1H-tetrazole-bonded sulfonic acid onto the surface of silica-coated magnetic nanoparticles using 3-chloropropyltriethoxysilane as a linker. The catalyst was characterized by XRD, TEM, FESEM, EDS, TG-DTA, and FT-IR. The ability and high activity of this catalyst were demonstrated in the synthesis of 1-carbamoyl-1-phenylureas with good to excellent yields via a new, simple and one-pot procedure in aqueous media under reflux conditions. This procedure has advantages such as high yields, short reaction times, a simple methodology and work-up process, green reaction conditions, high stability, catalytic activity, and easy preparation, separation and reusability of the catalyst. The synthesis of these compounds was confirmed by FT-IR, 1H NMR, 13C NMR and CHN. In addition, we investigated the biological properties of the 1-carbamoyl-1-phenylureas as newly synthesized compounds. The described catalyst could be easily separated from the reaction mixture by additional magnetic force and reused several times without a remarkable loss of its catalytic activity and any considerable changes in the product yield and the reaction time.